摘要
目的探讨血液灌流在治疗敌草快中毒患者中应用的效果。方法回顾分析德阳市人民医院2016年6月—2018年6月收治的敌草快中毒患者的病例资料。单纯行环磷酰胺、甲基强的松龙者,为对照组(14例),血液灌流联合环磷酰胺、甲基强的松龙治疗为观察组(49例),对比分析两组治疗效果。结果观察组患者第5天血肌酐、丙氨酸转氨酶、血乳酸较对照组患者明显降低(P<0.05);动脉血氧分压、14 d治疗成活率均较对照组明显增高,差异有统计学意义(P<0.05)。结论敌草快中毒后尚无特效解毒药,毒理作用机制尚不清楚。血液灌流联合环磷酰胺、甲基强的松龙的早期综合治疗手段一定程度改善了预后,为敌草快的治疗方案制定提供了参考。
Objective To investigate the effect of hemoperfusion in the treatment of patients with diguat dibromide poisoning.Methods The cases of patients with diguat dibromide poisoning in the people's hospital of Deyang from 2016.06 to 2018.06 were collected,and the the treatment effects of hemoperfusion combined with cyclophosphamide and methylprednisolone,and only drug treatment with cyclophosphamide and methylprednisolone were compared and analyzed.Results In the group of patients with hemoperfusion combined with cyclophosphamide and methylprednisolone treatment in the fifth day,the serum creatinine level was(168.58+85.78)umol/L,alanine aminotransferase was(132.87+82.58)U/L,and blood lactic acid was(5.02+2.56)mmol/L,which were significantly lower than the group only with cyclophosphamide and methylprednisolone treatment(P<0.05).The arterial partial pressure of oxygen was(79.69+12.43)mmHg,and the survival rate in the fourteenth day was 65.31%,which was significantly higher than the group only with cyclophosphamide and methylprednisolone treatment(P<0.05).Conclusions There is no specific antidote after diguat dibromide poisoning,and the toxicological mechanism is not clear.The early complex treatment of hemoperfusion combined with cyclophosphamide and methylprednisolone improves the prognosis,and provides a reference for the formulation of the treatment plan of diguat dibromide poisoning.
作者
鄢涛
谢雯雯
刘小琴
姜伟
杨勇
阳毅
余函阳
李芝霖
YAN Tao;XIE Wenwen;LIU Xiaoqin;JIANG Wei;YANG Yong;YANG Yi;YU Hanyang;LI Zhilin(The people's hospital of Deyang,Sichuan 618000,China)
出处
《中国急救复苏与灾害医学杂志》
2020年第8期962-964,共3页
China Journal of Emergency Resuscitation and Disaster Medicine
基金
四川省教育厅资助项目(编号:SWFZ16)。
关键词
敌草快
百草枯
中毒
血液灌流
甲基强的松龙
环磷酰胺
基层医院
成活率
Diguat dibromide
Poisoning
Hemoperfusion
Methylprednisolone
Cyclophosphamide
Primary hospitals
Survival rate
