摘要
子痫前期(pre-eclampsia)是一种妊娠期特有疾病,是造成孕产妇和围生儿死亡的重要原因之一,其发病机制尚未完全明确。近年来,研究表明妊娠相关血浆蛋白A(pregnancy-associated plasma protein-A,PAPP-A)和胎盘生长因子(placental growth factor,PlGF)在子痫前期的发生、发展中发挥重要作用。在子痫前期患者的外周血中PAPP-A及PlGF水平降低,导致血管损伤,抑制胎盘生长,进而胎盘缺血缺氧加重,促进并加重各器官功能障碍及母婴并发症的发生,两者降低的水平还与病情严重程度相关。根据PAPP-A、PlGF的生物学性质及其在母体血清中的表达水平,两者可作为预测子痫前期发生、发展的相关指标之一,并且经数据分析提示将两者联合预测效果更佳,可为子痫前期的早预防、早治疗提供依据。
Pre-eclampsia is a pregnancy-specific disease,which is one of the important causes of maternal and perinatal deaths.The pathogenesis of pre-eclampsia has not yet been fully clarified.In recent years,studies have shown that pregnancy-related plasma protein-A(PAPP-A)and placental growth factor(PlGF)play an important role in the occurrence and development of pre-eclampsia.In the peripheral blood of patients with pre-eclampsia,the decrease of PAPP-A and PlGF results in vascular damage,inhibits the growth of placenta,further aggravates the ischemia and anoxia of placenta,promotes and aggravates the occurrence of organ dysfunction and maternal infant complications.The decrease level of PAPP-A and PlGF is also related to the severity of the disease according to the biological properties of PAPP-A,PlGF and their expression level in maternal serum,they can be used as one of the relevant indexes to predict the occurrence and development of pre-eclampsia.The data analysis indicates that the combination of them is more effective in prediction,which can provide the basis for early prevention and early treatment of pre-eclampsia.
作者
祝淡抹
刘雪琼
卢丹(审校)
ZHU Dan-mo;LIU Xue-qiong;LU Dan(Clinical Medical College,Yangzhou University,Department of Obstetrics and Gynecology,Northern Jiangsu People′s Hospital,Yangzhou 215000,Jiangsu Province,China)
出处
《国际妇产科学杂志》
CAS
2020年第4期384-387,共4页
Journal of International Obstetrics and Gynecology
基金
江苏省妇幼健康科研项目(F201809)。
