摘要
子痫前期(PE)是导致围生期母婴死亡的主要原因之一,其发病机制目前尚不明确。近年研究表明,缺氧诱导因子(HIF)-1α及可溶性血管内皮生长因子受体(sFlt)-1,是导致及加重PE症状的2个重要因子。在PE患者外周血及胎盘组织中,HIF-1α表达增多,可促使靶基因sFlt-1表达增多,从而促进并加重孕妇血管损伤、各脏器功能障碍及母婴并发症的发生。根据HIF-1α及sFlt-1的生物学功能及其在PE患者外周血及胎盘组织中的表达水平,可作为预测PE发生、孕产妇并发症发生情况及围生儿预后的指标之一,为PE的早期预防、早期治疗,以及降低母儿并发症及死亡率,提供新的理论依据和途径。
Preeclampsia（PE）is one of the main causes of maternal and infant death,but its pathogenesis has not been fully clarified.Recent studies have indicated that hypoxia inducible factor（HIF）-1α and soluble fms-like tyrosine kinase receptor（sFlt）-1 are the two important factors leading to and aggravating the symptoms of PE.With the expression of HIF-1α in peripheral blood and placenta tissue of PE patients increased,it would prompted the increased expression of target gene sFlt-1,which led to maternal vascular injury and organ dysfunction,and maternal and neonatal complications occur.According to the biological function of HIF-1α and sFlt-1,and their expression levels in peripheral blood and placenta tissue of PE patients,it can be one of the prediction indicators of the occurrence of PE,maternal complications and prognosis of perineonate for early prevention and treatment,and provide a theoretical basis and a new way to reduce maternal and neonatal complications and mortality.
出处
《中华妇幼临床医学杂志（电子版）》
CAS
2017年第4期490-492,共3页
Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
基金
江苏省妇幼健康科研项目(F201663)~~
