摘要
目的探究前颞叶切除术对难治性颞叶癫痫患者简易智力状态检查量表(MMSE)评分、记忆能力的影响。方法回顾性分析2013年6月至2019年6月本院收治的104例难治性颞叶癫痫患者的临床资料,其中采取手术治疗的68例为观察组,采用药物治疗的36例为对照组,对比2组患者MMSE评分、记忆能力及社会功能。结果观察组治疗总有效率(95.59%)显著高于对照组(83.33%)(P<0.05);治疗后1个月及6个月,观察组MMSE评分均显著高于对照组及本组治疗前(P<0.05),对照组治疗后6个月MMSE评分高于本组治疗前(P<0.05);治疗后6个月,观察组操作智商(PIQ)、语言智商(VIQ)及总智商(FIQ)均显著高于对照组(P<0.05),且组内差异有统计学意义(P<0.05);观察组治疗后1个月记忆商(MQ)低于对照组(P<0.05),治疗后6个月MQ高于对照组(P<0.05);治疗后6个月,观察组社会功能、综合生活质量评分均显著高于对照组(P<0.05),且与治疗前、治疗后1个月相比差异有统计学意义(P<0.05);观察组治疗后有4例并发症,均经药物治疗后好转,无其他严重并发症。结论前颞叶切除术治疗难治性颞叶癫痫效果确切,可提高患者认知功能与记忆功能,改善社会行为功能,且术后并发症较少,具有较好的临床应用价值。
Objective To explore the effects of anterior temporal lobectomy on the mini-mental state examination(MMSE)score,memory of patients with intractable temporal lobe epilepsy.Methods 104 patients with refractory temporal lobe epilepsy admitted to our hospital from June 2013 to June 2019 were selected,of which 68 cases were treated surgically as the observation group and 36 cases were treated medically as the control group.MMSE score,memory and social functions were compared between the two groups.Results The total effective rate of the observation group was 95.59%,which was significantly higher than 83.33%of the control group(P<0.05).The MMSE score of the observation group was significantly higher than that of the control group at 1 month and 6 months after treatment(P<0.05);the MMSE score of the control group at 6 months after treatment was significantly higher than that before treatment(P<0.05).Six months after treatment,performance intelligence quotient(PIQ),verbal intelligence quotient(VIQ)and full intelligence quotient(FIQ)in the observation group were significantly higher than those in the control group(P<0.05),and there was significant difference between the two groups(P<0.05).The memory quotient(MQ)of observation group was lower than that of control group 1 month after treatment(P<0.05),and higher than that of control group six months after treatment(P<0.05).Six months after treatment,the scores of social function and comprehensive quality of life in the observation group were significantly higher than those in the control group(P<0.05),and there were significant differences between the two groups(P<0.05).There were 4 cases of complications in the observation group after treatment,all of them improved after drug treatment,without other serious complications.Conclusions Anterior temporal lobectomy is effective in the treatment of refractory temporal lobe epilepsy,it can improve cognitive and memory functions and social behavior function of patients,and has less complications after operation,with certain clinic
作者
钟旭光
王国福
林耀新
谢龙山
苏绮璇
侯小兵
叶虹
Zhong Xuguang;Wang Guofu;Lin Yaoxin;Xie Longshan;Su Qixuan;Hou Xiaobing;Ye Hong(Department of Functional Neurosurgery,the First People′s Hospital of Foshan,Foshan 528000,China)
出处
《中国医师杂志》
CAS
2020年第8期1212-1215,共4页
Journal of Chinese Physician
关键词
前颞叶切除术
癫痫
颞叶
耐药性癫痫
智力测验
记忆
Anterior temporal lobectomy
Epilepsy,temporal lobe
Drug resistant epilepsy
Intelligence tests
Memory
