摘要
目的:分析氯吡格雷联合拜阿司匹林治疗稳定型心绞痛(stable angina pectoris, SAP)的临床效果和安全性。方法 :选取100例SAP患者随机分为对照组和观察组各50例,对照组给予常规抗心绞痛治疗+拜阿司匹林用药方案,观察组在对照组基础上加用氯吡格雷。治疗3周后,对比两组临床疗效和不良反应、治疗前后血清炎性因子水平和凝血指标。结果 :观察组临床有效率显著高于对照组(P <0.05),而不良反应率无统计学差异(P> 0.05);与治疗前比较,两组治疗后血清炎性因子和凝血指标水平均降低,且观察组两指标水平均低于对照组(P <0.01)。结论 :氯吡格雷联合拜阿司匹林治疗SAP能够改善临床症状和血小板活化聚集,控制机体炎症反应水平,从而提高疗效和安全性。
Objective:To analyze the clinical effect and safety of clopidogrel combined with bayaspirin in the treatment of stable angina pectoris(SAP).Methods:One hundred cases of SAP patients were randomly divided into a control group and an observation group with 50 cases each.The control group was given conventional anti angina treatment plus bayaspirin medication and the observation group was given clopidogrel on the basis of the control group.The clinical efficacy and the incidence of adverse reactions were compared between the two groups 3 weeks after treatment.The levels of serum inflammatory factors and coagulation indexes were also compared before and after treatment.Results:The clinical effective rate of the observation group was significantly higher than that of the control group(P<0.05),but the incidence of adverse reaction had no statistical difference(P>0.05).The levels of serum inflammatory factors and coagulation indexes in the two groups were decreased after treatment and they were lower in the observation group than the control group(P<0.01).Conclusion:Clopidogrel combined with bayaspirin in the treatment of SAP can improve the clinical symptoms and platelet activation and aggregation and control the level of inflammatory reaction so as to improve the efficacy and safety.
作者
宫晓峰
王志杰
GONG Xiaofeng;WANG Zhijie(Beijing Mayinglong Changqing Anorectal Hospital,Beijing 100091,China)
出处
《上海医药》
CAS
2020年第17期14-16,46,共4页
Shanghai Medical & Pharmaceutical Journal
