摘要
目的:探讨早期下肢重复性训练促进急性脑梗死患者下肢功能恢复的效果。方法:将108例符合纳入标准的急性脑梗死患者按照随机数字表法分为2组,每组54例,两组均在发病48h内给予康复训练,对照组给予常规康复训练,观察组在常规康复训练基础上给予下肢重复性训练,比较两组治疗前后脑源性神经营养因子(BDNF)、神经元特异性烯醇化酶(NSE)和神经生长因子(NGF)水平,并比较两组治疗前及治疗第4周、第8周Fugl-Meyer量表下肢运动功能、平衡功能评分和功能性步行量表(FAC)评分。结果:治疗后两组血清BDNF、NSE水平降低(P<0.01),观察组降低更明显(P<0.01),两组NGF水平升高(P<0.01),观察组升高更明显(P<0.01),与对照组比较差异有显著性意义;治疗第4周、第8周时,观察组Fugl-Meyer运动功能、平衡功能评分显著高于对照组(P<0.01),治疗后观察组FAC等级显著高于对照组(P<0.05),差异均有显著性意义。结论:早期下肢重复性训练有利于改善血清BDNF、NSE、NGF水平,促进下肢运动、平衡和步行能力的提高,治疗急性脑梗死下肢功能障碍效果显著。
Objective:To investigate the effects of early repetitive training on lower limb function recovery in patients with acute cerebral infarction.Method:Totally 108 patients with acute cerebral infarction meeting inclusion criteria were divided into two groups according to the digital random table method, with 54 cases in each group. The patients of two groups were given the rehabilitation training within 48 h. The control group was given routine rehabilitation training,while the observation group was given repetitive training of lower limb besides the conventional rehabilitation training. Brain derived neurotrophic factor(BDNF), neuron specific enolization enzyme(NSE) and nerve growth factor(NGF) level of the two groups were compared before and after the treatment, and Fugl-Meyer scale for lower limb motor function, balance function score and functional ambulation category(FAC) scale score of the two groups were compared before treatment and after 4 or 8 weeks treatment.Result:The serum BDNF and NSE levels of the two groups reduced after treatment(P<0.01) with more significant reduction in the observation group(P<0.01). The NGF level of the two groups increased(P<0.01) with more obvious increase in the observation group(P<0.01), compared with the control group. The Fugl-Meyer motor function and balance function score of the observation group was significantly higher than that of the control group after 4 or 8 weeks treatment(P<0.01). The FAC grade was significantly higher than that of the control group after treatment with the statistically significant difference(P<0.01).Conclusion:Early lower limb repetitive training is effective in improving the serum BDNF, the NSE, NGF levels, promoting the lower limb movement, balance and walking ability and has significant effect in treating lower limb dysfunction for patients with acute cerebral infarction.
作者
王坤
李雅薇
王玉龙
WANG Kun;LI Yawei;WANG Yulong(Department of Rehabilitation Medicine,the First Affiliated Hospital of Shenzhen University,Shenzhen,Guangdong 518035)
出处
《中国康复医学杂志》
CAS
CSCD
北大核心
2020年第8期949-953,共5页
Chinese Journal of Rehabilitation Medicine
关键词
下肢重复性训练
急性脑梗死
运动
平衡
步行能力
lower extremity repetitive training
acute cerebral infarction
movement
balance
walking ability
