摘要
酒精性肝损伤是由于长期过量饮酒而导致的肝脏损害,严重时可导致肝细胞坏死,甚至引发肝功能衰竭。目前,寻找有效地干预酒精性肝损伤的活性物质成为各个领域研究的热点。多糖是重要的天然产物资源,广泛存在于植物、动物、真菌中,且安全无毒,具有保护肝脏的作用,能有效地治疗酒精性肝损伤,因此将多糖开发为干预酒精性肝损伤的新型药物具有较高的潜在价值。国内外对于多糖干预酒精性肝损伤的研究也日渐深入,发表了大量的研究结果。该综述从酒精性肝损伤的发病机制、干预酒精性肝损伤的多糖类型以及多糖干预酒精性肝损伤的作用机制进行了归纳总结,并对多糖在干预酒精性肝损伤方面的前景进行了展望,以期对后者的研究有一定的参考和借鉴价值。
Alcoholic liver disease(ALD)refers to liver damage caused by long-term heavy drinking,and can lead to hepatocellular necrosis and even liver failure in severe cases.The search for active substances with ameliorating effects on ALD has recently become a hot topic focus for researchers in various fields.Polysaccharides represent a major class of natural product,and are widely found in plants,animals,and fungi;they are safe and non-toxic,and can have protective effects on the liver,offering hope for an effective ALD treatment.Therefore,polysaccharides display high potential for development of new drugs for ALD.Research into the ameliorating effects of polysaccharides in ALD has rapidly proliferated,and a large number of research results have been published.This review summarizes the pathogenesis of ALD,the types of polysaccharides that can be used to treat ALD,and the mechanism underlying polysaccharide action in ALD,It also discusses future prospects for polysaccharide mediated intervention in ALD,in the hope of providing a frame of reference for future research.
作者
刘袆帆
朱珍
苏敏璇
王琴
吴晖
赖富饶
马路凯
曾楚君
朱淑娴
陈楚敏
林子慈
LIU Hui-fan;ZHU Zhen;SU Min-xuan;WANG Qin;WU Hui;LAI Fu-rao;MA Lu-kai;ZENG Chu-jun;ZHU Shu-xian;CHEN Chu-min;LIN Zi-ci(College of Light Industry and Food Sciences,Zhongkai University of Agriculture and Engineering,Guangzhou 510000,China;Lingnan Light Industry Teaching Department Guangzhou Light Industry Vocational School,Guangzhou 510650,China;School of Food Sciences and Engineering,South China University of Technology,Guangzhou 510640,China;Research Institude of Shaoguan Huagong High-tech Industry,Shaoguan 512027,China)
出处
《现代食品科技》
EI
CAS
北大核心
2020年第8期379-393,共15页
Modern Food Science and Technology
基金
广东省基础与应用基础研究基金项目(2019A1515011283)
广东省科技项目(2017A020108006)。
关键词
多糖
酒精性肝损伤
干预机制
polysaccharides
alcoholic liver disease
intervention mechanisms
