摘要
目的探讨血清中N末端B型利钠肽原(NT-ProBNP)、降钙素原(PCT)和白细胞介素-6(IL-6)表达水平在小儿胸外手术术后肺部感染的临床意义。方法选取2014年1月-2018年1月日照市中心医院确诊的80例胸外手术后肺部感染的患儿为感染组,同期选择50例胸外手术后未出现肺部感染的患儿作为非感染组。根据肺炎严重指数(PSI)评分将80例胸外术后发生肺部感染的患儿分为低危(n=37)、中危(n=28)及高危组(n=15)。使用酶联免疫荧光法检测血清NT-Pro BNP水平,电化学荧光法检测血清PCT和IL-6水平。结果血清PCT非感染组在<0.5 ng/ml水平的患儿数高于感染组,而感染组在其他三个浓度水平高于非感染组,差异具有统计学意义(P<0.05);感染组血清NT-Pro BNP、PCT与IL-6水平高于非感染组(P<0.05);高危组血清NT-Pro BNP、PCT、IL-6水平高于中危组和低危组,中危组血清NT-Pro BNP、PCT、IL-6水平又高于低危组,差异均有统计学意义(P<0.05);血清NT-Pro BNP、PCT与IL-6是判断肺部感染的独立要素。结论胸外术后出现肺部感染的患儿体内血清NT-Pro BNP、PCT与IL-6会出现异常升高,表明机体感染,其表达水平越高,提示病情越严重,对临床诊断肺部感染具有一定的参考价值。
OBJECTIVE To explore the clinical significance of serum N-terminal protype B natriuretic peptide(NT-ProBNP), procalcitonin(PCT), and interleukin-6(IL-6) in thoracic surgery children with postoperative pulmonary infection. METHODS Totally 80 children who underwent thoracic surgery and were diagnosed with postoperative pulmonary infection in Rizhao Central Hospital from Jan. 2014 to Jan. 2018 were assigned as the infection group, meanwhile, 50 children who underwent thoracis surgery but did not have postoperative pulmonary infection were set as the non-infection group. The 80 children with postoperative pulmonary infection were divided into the low risk group with 37 cases, the medium risk group with 28 cases and the high risk group with 15 cases according to the pneumonia severity index(PSI). The serum NT-Pro BNP level was detected by using enzyme-linked immunosorbent assay, and the levels of serum PCT and IL-6 were detected with the use of electrochemistry. RESULTS The number of the children with the serum PCT level less than 0.5 ng/ml was significantly larger in the non-infection group than in the infection group, while the levels of other three concentrations of the infection group were significantly higher than those of the non-infection group(P<0.05);the levels of serum NT-Pro BNP, PCT and IL-6 of the infection group were higher than those of the non-infection group(P<0.05);the levels of serum NT-Pro BNP, PCT and IL-6 of the high risk group were significantly higher than those of the medium risk group and the low risk group, and the levels of serum NT-Pro BNP, PCT and IL-6 of the medium risk group were significantly higher than those of the low risk group(P<0.05). The NT-Pro BNP, PCT and IL-6 were the independent factors for judgement of pulmonary infection. CONCLUSION The thoracic surgery children with postoperative pulmonary infection show abnormal rise of levels of serum NT-Pro BNP, PCT and IL-6, indicating that there is infection, the higher the expression levels, the more severer the illness condition is
作者
林维强
汤纪永
唐薇敏
宋全娜
胡明森
LIN Wei-qiang;TANG Ji-yong;TANG Wei-min;SONG Quan-na;HU Ming-sen(Rizhao Central Hospital,Rizhao,Shandong 276800,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2020年第13期2058-2062,共5页
Chinese Journal of Nosocomiology
基金
山东省科研基金资助项目(2018AS108)。
