摘要
目的探讨慢性阻塞性肺疾病急性加重(AECOPD)患者血清HMGB1,RAGE,TNF-α水平的变化及相关性。方法选取2018年8月~2019年7月在我院呼吸科诊治的AECOPD患者(AECOPD组)36例、慢性阻塞性肺疾病(COPD)稳定患者(STCOPD组)36例,健康查体者(对照组)36例,测定3组患者血清HMGB1,s-RAGE,TNF-α水平,分析其相关性。结果 AECOPD组、STCOPD组血清HMGB1,TNF-α水平显著高于对照组,sRAGE水平显著降低,差异均有显著性(P<0.05);与STCOPD组相比,AECOPD组血清HMGB1,TNF-α水平显著升高,sRAGE水平显著降低,且差异均有显著性(P<0.05)。随着COPD患者病情加重,血清HMGB1,TNF-α表达水平上调,血清sRAGE表达水平降低。血清HMGB1与sRAGE表达水平呈负相关(r=-0.546,P<0.05),血清HMGB1与TNF-α表达水平呈正相关(r=0.576,P<0.05),血清sRAGE与TNF-α表达水平呈负相关(r=-0.569,P<0.05)。结论血清HMGB1,TNF-α水平升高、sRAGE水平降低参与了AECOPD的病理过程,HMGB1-RAGE信号通路可能是导致AECOPD炎症反应加重的重要信号通路。
Objective To investigate the changes and correlation of serum HMGB1,RAGE and TNF-αin patients with AECOPD.Methods Thirty-six patients with acute exacerbation of chronic obstructive pulmonary disease(group AECOPD) and 36 patients with stable chronic obstructive pulmonary disease(group STCOPD) as well as 36 patients who were doing healthy check-up(group control) were selected.All the patients were detected the serum HMGB1,s-RAGE and TNF-α levels,and then correlation of HMGB1,sRAGE and TNF-α were analyzed.Results The serum HMGB1 and TNF-α levels in group AECOPD,group STCOPD were significantly higher than those in group control,and the level of sRAGE was significantly lower,which has significant difference(P<0.05).The Serum HMGB1 and TNF-α levels in group AECOPD were significantly higher than those in group STCOPD,and the level of sRAGE was significantly lower,and the differences were statistically significant(P<0.05).With the exacerbation of COPD patients,the expression levels of serum HMGB1 and TNF-α are up-regulated and the expression level of serum sRAGE is down-regulated.Serum HMGB1 was negatively correlated with sRAGE expression level(P<0.05),and serum HMGB1 was positively correlated with TNF-α expression level(P<0.05).Serum sRAGE was negatively correlated with TNF-α expression level(P<0.05).Conclusion The increase of serum HMGB1,TNF-α level and the decrease of sRAGE level participate in the pathological process of AECOPD;HMGB1-RAGE signal pathway may be an important signal pathway leading to aggravation of inflammatory response in AECOPD.
作者
高增艳
高艳艳
高福生
王晓敏
张增华
刘美娟
GAO Zengyan;GAO Yanyan;GAO Fusheng;WANG Xiaomin;ZHANG Zenghua;LIU Meijuan(Department of Respiratory Medicine,the Affiliated Hospital of Weifang Medical University,Weifang 261031,China;Department of Pathology,Yidu Central Hospital;Department of Respiratory Medicine,Weifang People's Hospital)
出处
《潍坊医学院学报》
2020年第3期187-189,共3页
Acta Academiae Medicinae Weifang
基金
潍坊市科技发展计划项目(项目编号:2018YX057)。
关键词
慢性阻塞性肺疾病急性加重
高迁移率族蛋白1
晚期糖基化终末产物受体
肿瘤坏死因子-α
Acute exacerbation of chronic obstructive pulmonary disease
High mobility group protein B1
Receptor for advanced glycation endproducts
Tumor necrosis factor-α
