摘要
目的探讨可溶性髓样细胞触发受体-1(sTREM-1)、白介素-6(IL-6)、微小核糖核酸-183(miR-183)在慢性阻塞性肺疾病(COPD)急性加重期患者中的表达及预后评估价值。方法回顾性选取2019年1月至2023年5月安阳钢铁集团有限责任公司职工总医院收治的85例COPD急性加重期患者作为观察组,同一时间选取88例稳定期COPD患者,将其作为对照组。检测所有研究对象血清sTREM-1、IL-6、血浆miR-183水平。根据随访1 a后观察组生存情况分为生存组、死亡组。比较不同组别血清sTREM-1、IL-6、血浆miR-183水平;Cox回归分析COPD急性加重期患者生存时间的影响因素。分析各指标联合检测对COPD急性加重期预后预测价值。结果观察组患者各指标水平比对照组高(P<0.05);死亡组各指标水平比生存组高(P<0.05);sTREM-1、IL-6、血浆miR-183均是影响COPD急性加重期的危险因素;三者联合预测COPD急性加重期预后的曲线下面积(AUC)值高于单项检测(P<0.05)。结论COPD加重期患者血清sTREM-1、IL-6、血浆miR-183水平均呈高表达,三者联合预测价值较好,可作为临床评估COPD加重期患者病情预后辅助参考依据。
Objective To investigate the expression and prognostic assessment value of soluble triggering receptor-1 expressed on myeloid cells(sTREM-1),interleukin-6(IL-6),and microRNAs-183(miR-183)in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods Eighty-five patients with acute exacerbation of COPD admitted to General Hospital of Anyang Iron&Steel Group Co.,LTD.from January 2019 to May 2023 were retrospectively selected as the observation group,and 88 patients with stable COPD were selected at the same time,and they were taken as the control group.Serum sTREM-1,IL-6 and plasma miR-183 levels were detected in all study subjects.According to the survival of the observation group after 1 year of follow-up,the group was divided into survival group and death group.Serum sTREM-1,IL-6,plasma miR-183 levels of different groups were compared.Cox regression analysis was performed to analyze the factors influencing survival time of patients with acute exacerbation of COPD.The prognostic value of the combined detection of each index in COPD acute exacerbation was analyzed.Results Patients in the observation group had higher levels of each indicator than those in the control group(P<0.05).Those in the death group had higher levels of each indicator than those in the survival group(P<0.05).sTREM-1,IL-6 and plasma miR-183 were risk factors affecting acute exacerbation of COPD,and the area under the curve(AUC)values of the three combined to predict the prognosis of acute exacerbation of COPD were higher than those of a single test(P<0.05).Conclusion Serum sTREM-1,IL-6 and plasma miR-183 levels were highly expressed in COPD exacerbation patients,and the combined predictive value of the three is good,which can be used as an auxiliary reference basis for clinical assessment of the prognosis of COPD exacerbation patients.
作者
刘改莲
刘待见
侯志慧
朱早君
苏郑刚
LIU Gailian;LIU Daijian;HOU Zhihui;ZHU Zaojun;SU Zhenggang(Department of Respiratory Medicine,General Hospital of Anyang Iron&Steel Group Co.,LTD.,Anyang 455000,China;Department of Respiratory and Critical Care Medicine,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《河南医学研究》
CAS
2024年第18期3365-3368,共4页
Henan Medical Research
