摘要
肝癌的治疗在近年取得了长足的进步。炎症在肝癌发生发展中扮演了重要角色,而阿司匹林可发挥抗炎作用。基础及临床研究发现,阿司匹林可抑制肝癌的发生发展,并辅助应用于肝癌综合治疗,协同其他药物发挥抗癌效应。阿司匹林成本低且易获取,因其在肝癌辅助治疗领域的潜力而引人注目,但在临床实践应用中仍存在诸多问题与困惑。对近年来阿司匹林在肝癌防治中的研究进展、现阶段面临问题及未来发展方向等进行总结及评述,以增加这一领域的认识及积累,为未来真实世界的临床应用奠定基础。
Great achievements have been made in the treatment of liver cancer in recent years.Inflammation plays an important role in the development and progression of liver cancer,while aspirin can exert an anti-inflammatory effect.Basic and clinical studies have found that aspirin can inhibit the development and progression of liver cancer,assist in the comprehensive treatment of liver cancer,and exert an anticancer effect together with other drugs.Aspirin has low costs and is easy to access,and its potential in the adjuvant therapy for liver cancer has attracted great attention;however,there are still many problems and confusions in the application of aspirin in clinical practice.This article summarizes and reviews the recent research advances in aspirin in the prevention and treatment of liver cancer,the problems faced at present,and the future development direction,in order to improve the understanding of this field and lay a foundation for clinical application in the real world in the future.
作者
巴桃桃
肖鹏
丁梦梦
高沿航
BA Taotao;XIAO Peng;DING Mengmeng;GAO Yanhang(Department of Hepatology,The First Hospital of Jilin University,Changchun 130021,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第8期1847-1851,共5页
Journal of Clinical Hepatology
基金
国家自然科学基金资助项目(81972265)
国家重点研发计划“精准医学研究”专项(2017YFC0908103)
“艾滋病和病毒性肝炎等重大传染病防治”国家科技重大专项(2017ZX10202202,2018ZX10302206)
吉林大学白求恩计划项目(2018B32)
吉林大学高层次创新团队建设项目(2017TD-08)
中央高校基本科研业务费专项资金。
关键词
肝肿瘤
阿司匹林
治疗学
liver neoplasms
aspirin
therapeutics
