摘要
目的探讨伽玛刀治疗脑转移瘤对病人认知功能及生活质量的影响。方法回顾性分析64例脑转移瘤病人的临床资料,按治疗方案不同分为伽玛刀组32例(单纯伽玛刀治疗)和联合治疗组32例(伽玛刀联合全脑放疗)。采用MoCA评分评估病人的认知功能,采用EORTC QLQ-C30中文版评估病人的生活质量,并进行统计分析。结果两组肿瘤局部控制率、1年生存率差异均无统计学意义(P>0.05)。术后3、6、12个月,伽玛刀组MoCA评分及躯体功能、情绪功能、角色功能、社会功能评分均明显高于联合治疗组(P <0.05)。结论单纯伽玛刀治疗脑转移瘤是一种安全、有效的治疗方法,对病人认知功能和生活质量的影响较小。
Objective To investigate the effects gamma knife treatment on cognitive function and quality of life in patients with brain metastases. Methods Clinical data of 64 patients with brain metastasis were analyzed retrospectively. The patients were equally divided into gamma knife group and combination treatment group based on the different therapeutic schedules, and the gamma knife group was treated by gamma knife radiosurgery alone, while the combination treatment group by gamma knife radiosurgery combined with whole brain radiation therapy. The cognitive function was assessed by Mo CA scores, and the quality of life was assessed by EORTC QLQ-C30 Chinese version, then the data were analyzed statistically. Results There was no statistical difference in the tumor local control rate and 1-year survival rate between the two groups(P > 0.05). The somatic function, emotional function, role function, social function and Mo CA scores in the gamma knife group were obviously higher than in the combination treatment group 3, 6, 12 months after the surgery(P < 0.05). Conclusion Gamma knife radiosurgery alone is an effective and safe treatment method for brain metastases, with less influence on the patients’ cognitive function and quality of life.
作者
赵东海
杜汉强
王嘉嘉
张聿浩
刘祈成
成红梅
邹海强
梁军潮
Zhao Donghai;Du Hanqiang;Wang Jiajia;Zhang Yuhao;Liu Qicheng;Cheng Hongmei;Zou Haiqiang;Liang Junchao(Department of Neurosurgery,General Hospital of Southern Theatre Command,Guangzhou,Guangdong 510010,China)
出处
《中国微侵袭神经外科杂志》
CAS
2020年第5期205-208,共4页
Chinese Journal of Minimally Invasive Neurosurgery
基金
广东省科技计划项目(编号:2013B051000067)。
关键词
脑转移瘤
伽玛刀
全脑放疗
认知功能
生活质量
brain metastases
gamma knife
whole brain radiation therapy
cognitive function
quality of life
