摘要
目的 探究对非小细胞肺癌脑转移患者行脑转移瘤γ刀立体定向放射治疗的临床疗效及对相关指标及并发症的影响。方法 回顾性分析2020年10月—2022年10月徐州矿务集团总医院收治的75例非小细胞肺癌脑转移患者的临床病理资料,行全脑放疗的肺癌脑转移患者设为对照组(n=37),行γ刀立体定向放射治疗的患者设为观察组(n=38)。对比两组患者的肿瘤相关因子情况、治疗效果、颅内并发症发生率及3、6、12个月的生存情况。结果 观察组患者肿瘤坏死因子-β_(1)(tumor necrosis factor β_(1),TNF-β_(1))、血管内皮生长因子(vascular endothelial growth factor,VEGF)、基质金属蛋白酶2(matrix metalloproteinase 2,MMP-2)、金属蛋白酶组织抑制剂(tissue inhibitors of metalloproteinases,TIMP)均显著低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为84.21%,高于对照组的62.16%,差异有统计学意义(χ^(2)=4.660,P<0.05)。观察组颅内并发症发生率低于对照组,差异有统计学意义(P<0.05)。观察组第3、6、12个月的生存率明显高于对照组,差异有统计学意义(P<0.05)。结论 在非小细胞肺癌脑转移患者的治疗过程中,相比全脑放射治疗,应用γ刀立体定向放射治疗方式优势明显,其具有显著治疗效果,有助于提高患者的生存时间,同时降低颅内并发症的发生率。
Objective To explore the clinical efficacy of γ knife stereotactic radiotherapy for brain metastases in patients with non-small cell lung cancer (NSCLC) and its influence on related indexes and complications.Methods The clinicopathological data of 75 patients with brain metastasis of non-small cell lung cancer admitted to Xuzhou Mining Group General Hospital from October 2020 to October 2022 were retrospectively analyzed.The patients with brain metastasis of lung cancer who underwent whole brain radiotherapy were set as the control group (n=37),and the patients who underwent gamma knife stereotactic radiotherapy were set as the observation group (n=38).The tumorrelated factors,treatment effect,incidence of intracranial complications and survival at 3,6 and 12 months were compared between the two groups.Results The levels of tumor necrosis factor-β_(1) (TNF-β_(1)),vascular endothelial growth factor (VEGF),matrix metalloproteinase 2(MMP-2) and tissue inhibitors of metalloproteinases (TIMP) in the observation group were significantly lower than those in the control group,the difference was statistically significant (P<0.05).The total effective rate of treatment in the observation group was 84.21%higher than that in the control group (62.16%),and the difference was statistically significant (χ^(2)=4.660,P<0.05).The incidence of intracranial complications in the observation group were lower than that in the control group,the differences were statistically significant (P<0.05).The survival rates of the observation group at the 3 rd,6 th and 12 th months were significantly higher than those of the control group,and the differences were statistically significant (P<0.05).Conclusion In the treatment of patients with brain metastases of non-small cell lung cancer,compared with whole brain radiotherapy,the application of gamma γ stereotactic radiotherapy has obvious advantages,which has significant therapeutic effect,helps to improve the survival time of patients,while reducing the incidence of intracranial complicatio
作者
祁红
朱盼荣
张旭东
QI Hong;ZHU Panrong;ZHANG Xudong(Department of Stereotactic Radiotherapy,Xuzhou Mining Group General Hospital,Xuzhou,Jiangsu Province,221000 China)
出处
《世界复合医学》
2023年第5期27-30,共4页
World Journal of Complex Medicine
关键词
γ刀立体定向放射治疗
肺癌
脑转移瘤
效果
并发症
γknife stereotactic radiotherapy
Lung cancer
Brain metastases
Effect
Complication
