摘要
目的探讨左西孟旦对急性ST段抬高型心肌梗死并急性心力衰竭患者的治疗价值,及其对患者QT离散度和室性心律失常的影响。方法选取济宁医学院附属湖西医院2018年9月至2019年8月收治的82例急性ST段抬高型心肌梗死并急性心力衰竭患者作为研究对象,利用随机数字表法将其分为对照组和研究组,每组41例。对照组予以临床常规治疗,研究组予以常规治疗+左西孟旦治疗,记录两组治疗效果、治疗前后心电图指标变化情况及不良反应发生情况。结果研究组总有效率(87.80%,36/41)高于对照组(65.85%,27/41),差异有统计学意义(P<0.05)。治疗前,两组患者频发室性期前收缩、短暂室性心动过速、QT离散度、校正QT离散度检查结果比较,差异均未见统计学意义(P均>0.05);治疗后,研究组上述指标检查结果与治疗前比较差异未见统计学意义(P>0.05),对照组上述指标与治疗前比较差异有统计学意义(P<0.05)。研究组、对照组用药期间不良反应发生率比较差异未见统计学意义(P>0.05)。结论应用左西孟旦有利于提高急性ST段抬高型心肌梗死并急性心力衰竭患者的临床疗效,确保患者临床用药安全性。
Objective To investigate the therapeutic effects of levosimendan on patients with acute ST-segment elevation myocardial infarction(STEMI)complicated by acute heart failure(AHF),and its effects on patient’s QT dispersion(QTd)and ventricular arrhythmia.Methods Eighty-two patients with acute STEMI complicated by AHF admitted to Huxi Hospital Affiliated to Jining Medical College from September 2018 to August 2019 were selected as the study objects.All the patients were randomly divided into control group and study groups by random number table method,with 41 cases in each group.The control group received routine clinical treatment,while the study group received routine treatment+levosimendan.The treatment effects,changes of electrocardiogram indicators before and after treatment,and adverse reactions of the two groups were recorded.Results The total effective rate of the study group(87.80%,36/41)was significantly higher than that of the control group(65.85%,27/41),P<0.05.Before treatment,there was no significant difference between the two groups in the results of frequent ventricular premature contraction,transient ventricular tachycardia,QTd,or corrected QTd(all P>0.05).Compared to the levels prior to treatment,the above indicators had no significant difference in the study group after treatment(P>0.05),but had significant differences in the control group after treatment(P<0.05).There was no significant difference in the incidence of adverse reactions during drug treatment between the study group and the control group(P>0.05).Conclusions Levosimendan can improve the clinical efficacy of patients with acute STEMI complicated by AHF,and ensure the safety of clinical medication.
作者
李凤玲
马林
程林
Li Fengling;Ma Lin;Cheng Lin(Department of Cardiology,Huxi Hospital Affiliated to Jining Medical College,Heze 274300,China)
出处
《中国实用医刊》
2020年第9期114-117,共4页
Chinese Journal of Practical Medicine
