摘要
目的探讨过敏性鼻炎患者血清IgE及相关细胞因子(TNF-α、IL-4、IL-12)水平变化及其临床意义;方法选择我院2018年6月至2020年6月耳鼻喉科收治的过敏性鼻炎患者33例,同时选取同期29例我院的健康体检者,两组患者性别、年龄、BMI等一般资料比较,差异无统计学意义,所有患者采用酶联免疫吸附法检测IgE、TNF-α、IL-4和IL-12水平,并采用t检验分析两组患者间上述指标差异;结果本研究中,共检测62例患者血清IgE及相关细胞因子水平。其中与健康体检组相比,过敏性鼻炎组患者血清IgE、TNF-α、IL-4水平显著增加,差异有统计学意义(P<0.05),同时过敏性鼻炎组患者血清IL-12水平显著降低,差异有统计学意义(P<0.05);结论过敏性鼻炎患者血清IgE、TNF-α、IL-4水平显著增加,同时IL-12水平显著降低,上述变化与过敏性鼻炎的发病过程有关,有助于判断该部分患者的治疗及预后。
Objective To investigate the changes and clinical significance of serum IgE and related cytokines (TNF-α,IL-4,IL-12) in patients with allergic rhinitis;Methods selection ENT in our hospital from June 2018 to June 2020 Thirty-three patients with allergic rhinitis admitted by the department and 29 healthy medical examiners in our hospital during the same period were selected.There was no statistically significant difference between the two groups in terms of gender,age,BMI and other general information.All patients were tested by enzyme-linked immunosorbent assay The levels of IgE,TNF-α,IL-4 and IL-12 were analyzed by t test to analyze the differences between the two groups of patients.Results In this study,a total of 62 patients were tested for serum IgE and related cytokine levels.Compared with the healthy physical examination group,the serum IgE,TNF-α and IL-4 levels in patients with allergic rhinitis increased significantly,the difference was statistically significant (P<0.05),and the serum IL-12 levels in patients with allergic rhinitis were significant Decreased,the difference was statistically significant (P<0.05);Conclusion Serum IgE,TNF-α,IL-4 levels in patients with allergic rhinitis were significantly increased,while IL-12 levels were significantly reduced.The above changes are related to the pathogenesis of allergic rhinitis,Help to judge the treatment and prognosis of these patients.
作者
徐穷
Xu Qiong(Department of Clinical Laboratory,Pingshan County Hospital of traditional Chinese Medicine,Sichuan,Yibin,645350,China)
出处
《中国医学文摘（耳鼻咽喉科学）》
2020年第4期243-245,共3页
Chinese Medical Digest(Otorhinolaryngology)
