摘要
目的利用人工面神经(artificial facial nerve,AFN)诱发单侧失神经支配兔的口轮匝肌收缩,探讨AFN诱发闭口时刺激电流的最适参数匹配组合情况。方法按照不同刺激参数组合,在不同时间点于清醒状态下经AFN体内刺激兔患侧口轮匝肌诱发其收缩,记录各组合下阈刺激、峰刺激的电流强度值,进而比较不同组合下刺激消耗的总电荷量。结果比较不同刺激频率、脉宽匹配组合下AFN的阈刺激消耗总电荷量及峰刺激消耗总电荷量,发现不同组间的频率因素、脉宽因素以及频率与脉宽的交互作用因素对总电荷的影响,差异均存在统计学意义(P值均<0.05)。结论当AFN刺激频率为60 Hz,刺激波宽为100μs时,在达到有效诱发麻痹口轮匝肌收缩的前提下,输出刺激电流强度相对最低、消耗的总电荷量最低,适合作为满足AFN低功耗要求的优选刺激参数组合方案。
Objective To explore the optimal matching of the current parameters about artificial facial nerve (AFN) for inducing contraction of the orbicularis oris muscle (OOM) in rabbit with peripheral facial paralysis.Methods According to the combinations of different stimulus parameters, at different time points, we used AFN to induce contraction of the affected side OOM of the paralyzed rabbit in waking state. We recorded the current amplitudes of the threshold stimulation and peak stimulation under each combination, then compared the total charge of the stimulus consumption under different combinations.Results Compared the total stimulus charge consumption of the AFN threshold stimulation and that in the peak stimulation respectively under different stimulus frequency and pulse width matching combinations, we found that the frequency, the pulse width and the interaction of the frequency and pulse width among different groups could affect the total charge, the differences were statistically significant (P<0.05).Conclusions When AFN stimulus frequency is 60 Hz and the stimulus pulse width is 100 μs, the output current intensity is relatively lowest and the total consumed charge is the lowest under the premise of effectively inducing the paralytic side OOM contraction. Thus we recommend this stimulus parametric combination as the optimal combination for meeting the low power consumption of AFN.
作者
许栋岳
孙雅静
赵宁军
罗丹
赵艳霞
李克勇
Xu Dongyue;Sun Yajing;Zhao Ningjun;Luo Dan;Zhao Yanxia;Li Keyong(Department of Otorhinolaryngology,Affiliated Hospital of Chifeng University,Chifeng 024050,China;Department of Otorhinolaryngology Head and Neck Surgery,Shanghai General Hospital of Shanghai Jiaotong University,Shanghai 200080,China)
出处
《中华耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2020年第6期615-619,共5页
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
基金
国家自然科学基金面上项目(81070779)
上海市科委重点科技攻关项目(1441902000)。
关键词
面神经麻痹
人工面神经
口轮匝肌
电刺激
Facial paralysis
Artificial facial nerve
Orbicularis oris muscle
Electric stimulation
