摘要
目的探讨猴耳环消炎颗粒辅助治疗对婴幼儿过敏性结肠炎(AC)肠内环境的影响。方法采用回顾性研究方法,选取2016年7月至2019年6月海口市第三人民医院收治的AC患儿96例,按治疗方案不同将其分为两组:对照组和观察组,每组各48例。对照组患儿予以常规对症支持治疗,观察组患儿在对照组基础上予以猴耳环消炎颗粒辅助治疗。比较两组患儿的临床疗效、不良反应发生率、症状改善时间、治疗前后肠内环境、炎症反应[血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]、免疫状态(血清IgA、IgG、IgM水平)。结果观察组患儿的总有效率95.83%(46/48)高于对照组77.08%(37/48),差异具有统计学意义(P<0.05);观察组患儿的排便次数恢复时间[(3.21±1.28)d]、大便性状恢复时间[(3.69±1.18)d]、白细胞水平恢复时间[(4.01±0.98)d]、进普食恢复时间[(7.13±1.59)d]均短于对照组,差异具有统计学意义(P<0.05);治疗后,观察组患儿的尿液乳果糖(0.09±0.01)%、乳果糖/甘露醇(0.08±0.03)降低,且观察组低于对照组,观察组甘露醇(1.17±0.40)%高于对照组,差异均具有统计学意义(P<0.05);治疗后,两组患儿的血清IL-6(21.45±5.01)μg/L、IL-8(25.13±4.81)ng/L、TNF-α(10.95±1.34)ng/L、IgA(1.35±0.26)g/L、IgG(12.59±2.13)g/L、IgM(1.63±0.28)g/L水平均降低,且观察组低于对照组,差异均具有统计学意义(P<0.05);观察组不良反应发生率为0(0/48),与对照组[2.08%(1/48)]比较,差异无统计学意义(P>0.05)。结论猴耳环消炎颗粒辅助治疗婴幼儿AC能从改善肠内环境、调节免疫及缓解炎症反应等方面进一步提高治疗效果,促进康复,且不增加不良反应发生风险。
Objective To investigate the effect of adjuvant therapy of Houerhuan xiaoyan granules on the intestinal environment of infantile allergic colitis(AC).Methods A retrospective study was used to select 96 children with AC who were admitted to the Third People's Hospital of Haikou from July 2016 to June 2019,they were divided into two groups according to the treatment plan:control group and observation group,with 48 cases in each group.The control group was given conventional symptomatic supportive treatment,and the observation group was given adjuvant therapy with Houerhuan xiaoyan granules on the basis of the control group.The clinical efficacy,incidence of adverse reactions,time to symptom improvement,intestinal environment,inflammatory response[serum interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)],immune status(serum IgA,IgG,IgM levels)before and after treatment of the two groups were compared.Results The total effective rate of children in the observation group was 95.83%(46/48),which was higher than that in the control group 77.08%(37/48),the difference was statistically significant(P<0.05);in the observation group,the number of bowel movements(3.21±1.28)d,stool traits(3.69±1.18)d,recovery of white blood cell levels(4.01±0.98)d,and recovery of general diet(7.13±1.59)d were shorter than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the urine lactulose(0.09±0.01)%and lactulose/mannitol(0.08±0.03)of children in the observation group decreased,and the observation group was lower than the control group,the mannitol(1.17±0.40)%in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05);after treatment,the serum IL-6(21.45±5.01)μg/L,IL-8(25.13±4.81)ng/L,TNF-α(10.95±1.34)ng/L,IgA(1.35±0.26)g/L,IgG(12.59±2.13)g/L,IgM(1.63±0.28)g/L levels of the two groups of children decreased,and the observation group was lower than the control group,the differences were statis
作者
邢东文
符艺影
王华
林坚
陈小兵
XING Dong-wen;FU Yi-ying;WANG Hua(Department of Pediatrics,Haikou Third People's Hospital,Haikou Hainan 571100,China)
出处
《临床和实验医学杂志》
2020年第14期1504-1507,共4页
Journal of Clinical and Experimental Medicine
基金
海南省卫计委科研项目(编号:1801032034A2005)。
关键词
婴幼儿
过敏性结肠炎
猴耳环消炎颗粒
肠内环境
炎症
反应
免疫状态
Infants
Allergic colitis
Houerhuan xiaoyan granules
Intestinal environment
Inflammatory response
Immune status
