摘要
[目的]探究清胰汤合剂联合奥拉咪唑对急性胰腺炎患者调节性T细胞(Treg)和辅助性T细胞1/辅助性T细胞2(Th1/Th2)水平的影响。[方法]206例急性胰腺炎患者被随机分配到中西药结合治疗实验组(107例)或对照组(99例)。所有受试者均接受常规治疗维持器官功能,实验组同时进行清胰汤合剂联合奥拉咪唑给药治疗,受试者分别在入院后第1、3、7和14天检测炎症细胞因子IL-6、IL-10、肿瘤坏死因子-α,免疫学标志物:人类白细胞DR抗原(HLA-DR)、Treg、Th1/Th2、尿乳果糖/甘露醇(LMR)、内毒素水平。[结果]患者的总死亡率为11.17%(23/206),实验组的死亡率显著低于对照组(4.67%、18.18%,χ~2=3.897,P<0.05)。实验组和对照组在第7天和第14天的IL-6、IL-10、肿瘤坏死因子-α、LMR和内毒素水平均显著低于第1天(P<0.01),而第14天实验组的免疫学标志物水平显著低于对照组(P<0.01或0.05)。实验组和对照组在第7天内,Treg和Th1/Th2比值都相应增加(相比第1天P<0.01),但第14天实验组和对照组的Treg水平和Th1/Th2差异有统计学意义(P<0.01)。[结论]清胰汤合剂联合奥拉咪唑对急性胰腺炎患者的免疫功能具有明显的改善作用。
[Objective]To explore the effects of Qingyi decoction combined with olamidazole on the levels of regulatory T cells(Treg)and helper T cells 1/helper T cells 2(Th1/Th2)in patients with acute pancreatitis.[Methods]Two hundred and six early acute pancreatitis patients who agreed to receive combined treatment of traditional Chinese and Western medicine were randomly assigned to the experimental group(107)or control group(99).All subjects received conventional therapy to support organ function.The experimental group also received traditional Chinese medicine preparation combined with omeprazole.Cytokines(IL-6,IL-10,and TNF-α),immunological markers(HLA-DR,Treg,and Th1/Th2),endotoxin levels and urinary lactulose/mannitol ratios were measured.[Results]The total mortality rate was 11.17%,which was signifcantly lower in the experimental group(4.67%)than in the control group(18.18%,χ2=3.897,P<0.05).Serum IL-6,IL-10,TNF-α,lactulose/mannitol ratio and endotoxin levels were signifcantly lower at day 7 and day 14 than at day 1 in both experimental and control groups(P<0.01).Immunological markers were signifcantly lower in the experimental group than those in the control group at day 14(all P<0.01 or P<0.05).Treg cell prevalence and Th1/Th2 cell ratios deteriorated within 7 days in both groups(P<0.01 vs day 1),but signifcant differences in Treg levels and Th1/Th2 cell ratio between experimental and control groups were observed at day 14(P<0.01).[Conclusion]Qingyi decoction mxture combined with olamidazole can significantly improve the immune function of patients with acute pancreatitis.
作者
许霞
鄢家苗
XU Xia;YAN Jia-miao(Department of Pharmacy,Ankang Traditional Chinese Medicine Hospital,Ankang 725000,China)
出处
《中国中西医结合消化杂志》
CAS
2020年第4期296-300,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
