摘要
目的探讨α-羟丁酸脱氢酶(α-HBDH)在妊娠期肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy,ICP)患者中的表达水平及与不良妊娠结局的相关性。方法选取2016年12月-2018年12月期间住院分娩的ICP孕妇120名作为观察组,另以同期住院分娩的健康孕妇120名作为对照组。比较两组的血清总胆汁酸(TBA)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、α-羟丁酸脱氢酶(α-HBDH)水平。将观察组分为重度患者与轻度患者,比较重度与轻度患者的上述血清指标及妊娠结局。采用Spearman相关分析血清指标与妊娠结局的相关性。结果观察组血清TBA、AST、ALT、α-HBDH显著高于对照组(P<0.05)。重度患者的血清TBA、AST、ALT、α-HBDH显著高于轻度患者(P<0.05)。轻度与重度患者2组新生儿窒息、羊水污染、低出生体质量儿的差异无统计学意义(P>0.05)。重度患者中胎儿窘迫、早产发生率显著高于轻度患者(P<0.05)。TBA、AST、ALT、α-HBDH均与妊娠结局呈显著正相关,TBA、AST、ALT、α-HBDH水平越高,出现不良妊娠结局的风险越高(P<0.05)。结论ICP患者α-HBDH水平异常升高,且重度患者高于轻度患者,同时重度患者胎儿窘迫、早产发生率相对轻度患者更高,血清TBA、AST、ALT、α-HBDH越高,不良妊娠结局风险越大。
Objective To investigate the expression level ofα-hydroxybutyrate dehydrogenase(α-HBDH)in patients with intrahepatic cholestasis of pregnancy(ICP)and its association with adverse pregnancy outcomes.Methods 120 pregnant women with ICP who were hospitalized and delivered between December 2016 and December 2018 were selected as the observation group,and 120 healthy pregnant women who were hospitalized and delivered during the same period were selected as the control group.Serum total bile acid(TBA),aspartate aminotransferase(AST),alanine aminotransferase(ALT),andα-hydroxybutyrate dehydrogenase(α-HBDH)levels were compared between the two groups.The observation components were divided into severe patients and mild patients,and the above-mentioned serum indexes and pregnancy outcomes of severe and mild patients were compared.Spearman correlation was used to analyze the correlation between serum indexes and pregnancy outcomes.Results The serum TBA,AST,ALT,andα-HBDH were significantly higher in the observation group than in the control group(P<0.05).The serum TBA,AST,ALT,andα-HBDH were significantly higher in patients with severe disease than in mild patients(P<0.05).There was no significant difference between the two groups(P>0.05).The incidence of fetal distress and premature delivery in severe patients was significantly higher than that in mild patients(P<0.05).TBA,AST,ALT,andα-HBDH were significantly positively correlated with pregnancy outcomes.The higher the levels of TBA,AST,ALT,andα-HBDH,the higher the risk of adverse pregnancy outcomes(P<0.05).Conclusion The level ofα-HBDH in patients with ICP is abnormally elevated,and the severity of patients is higher than that of mild patients.At the same time,the incidence of fetal distress and premature delivery is higher in patients with severe disease,and the higher the serum TBA,AST,ALT,α-HBDH,and adverse pregnancy,the greater the risk of ending.
作者
刘晋英
LIU Jinying(Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine(Futian),Shenzhen 518000,China)
出处
《现代医院》
2020年第8期1247-I0001,共3页
Modern Hospitals
关键词
妊娠期肝内胆汁淤积症
Α-羟丁酸脱氢酶
严重程度
妊娠结局
生化指标
Intrahepatic cholestasis of pregnancy
Α-hydroxybutyrate dehydrogenase
Severity
Pregnancy outcome
Biochemical indicators
