摘要
目的:探讨茵栀黄口服液联合熊去氧胆酸对妊娠期肝内胆汁淤积症(Intrahepatic Cholestasis of Pregnancy,ICP)患者的临床疗效。方法:将113例ICP患者随机分为观察组(67例)和对照组(66例),对照组患者口服熊去氧胆酸片,观察组患者口服茵栀黄口服液联合熊去氧胆酸,疗程均为14 d。比较两组患者临床疗效、肝功能指标、瘙痒症状评分以及不良妊娠结局。结果:观察组患者治疗总有效率高于对照组,差异有统计学意义(P <0.05);观察组患者治疗后总胆红素(Total bilirubin,TB)、总胆汁酸(Total Bile Acid,TBA)水平以及瘙痒症状评分均有明显降低,且低于对照组,差异有统计学意义(P <0.05);观察组患者发生早产,羊水污染以及胎儿宫内窘迫等不良妊娠结局情况均低于对照组,差异有统计学意义(P <0.05)。结论:茵栀黄口服液联合熊去氧胆酸可改善ICP患者肝功能,改善临床症状,减少不良妊娠结局的发生,有效提高临床疗效。
Objective: To investigate the clinical efficacy of the Yinzhihuang oral solution( 茵栀黄口服液) with ursodeoxycholic acid on ICP. Methods: 113 patients with ICP were randomly divided into the observation group(67 cases) and the control group(66 cases). The control group patients received ursodeoxycholic acid tablets, and the observation group received the Yinzhihuang oral solution with ursodeoxycholic acid. The course of treatment was 14 days. The clinical efficacy, liver function index, pruritus score and adverse pregnancy outcome were compared between the two groups. Results: The total effective rate in the observation group was higher than that in the control group, and the difference was statistically significant(P<0.05). The TB, TBA levels and pruritus scores in the observation group were significantly reduced, and were lower than the control group(P<0.05). The adverse pregnancy outcomes such as premature birth, amniotic fluid contamination, and intrauterine distress in the observation group were lower than those in the control group, and the difference was statistically significant(P<0.05). Conclusion: The Yinzhihuang oral liquid with ursodeoxycholic acid can improve liver function, improve clinical symptoms, reduce the occurrence of adverse pregnancy outcomes, and effectively improve clinical efficacy.
出处
《中医临床研究》
2020年第11期140-142,共3页
Clinical Journal Of Chinese Medicine
关键词
妊娠期肝内胆汁淤积症
茵栀黄
熊去氧胆酸
疗效
Intrahepatic cholestasis during pregnancy
Yin Zhihuang
Ursodeoxycholic acid
Efficacy
