摘要
目的探究低剂量地塞米松预处理对乳腺癌术后患者化疗引起的不良反应及生活质量的影响。方法选取2018年5月~2019年5月我院收治的80例乳腺癌术后化疗患者作为研究对象,按照随机数字表法分为预处理组和非预处理组,各40例。均在术后接受TAC化疗方案,预处理组在化疗前静脉推注地塞米松,非预处理组在化疗前未给予任何干预措施,比较两组化疗后恶心呕吐发生程度、恶心呕吐持续天数、生活质量及安全性。结果预处理组呕吐、恶心程度低于非预处理组,差异有统计学意义(P<0.05);预处理组恶心、呕吐持续天数低于非预处理组[(1.63±0.76)d vs(3.06±1.35)d]、[(0.54±0.19)d vs(1.94±0.63)d],差异有统计学意义(P<0.05);预处理组食欲、精神、睡眠、疲乏、疼痛、对治疗态度、日常生活、治疗副作用、面部表情得分及总分高于非预处理组,差异有统计学意义(P<0.05);两组家庭理解与配合、同事的理解与配合、自身对癌症认识得分比较,差异无统计学差异(P>0.05)。预处理组在化疗前后检查尿常规、大便常规、小便常规、血生化分析、心电图等指标均未发现与激素干预相关的波动。结论在乳腺癌术后患者化疗前给予小剂量地塞米松预处理,可缓解患者化疗引起的恶心、呕吐等不良反应,提高生活质量,安全有效。
Objective To explore the effect of low-dose dexamethasone pretreatment on adverse reactions and quality of life caused by chemotherapy for breast cancer patients.Methods From May 2018 to May 2019,80 cases of breast cancer patients undergoing chemotherapy after surgery in our hospital were selected as the research object.They were divided into pretreatment group and non-pretreatment group according to random number table method,40 cases each.All patients received TAC chemotherapy after surgery.The pretreatment group received intravenous injection of dexamethasone before chemotherapy.The non-pretreatment group did not give any intervention before chemotherapy.Compare the incidence of nausea and vomiting after chemotherapy,the number of days of nausea and vomiting,quality of life and safety.Results The degree of vomiting and nausea in the pretreatment group was lower than that in the non-pretreatment group,the difference was statistically significant(P<0.05);the duration of nausea and vomiting in the pretreatment group was lower than that in the non-pretreatment group[(1.63±0.76)d vs(3.06±1.35)d],[(0.54±0.19)d vs(1.94±0.63)d],the difference was statistically significant(P<0.05);appetite,mental,sleep,fatigue,pain,attitude towards treatment,daily Life,treatment side effects,facial expression score and total score were higher than non-pretreatment group,the difference was statistically significant(P<0.05);There was no significant difference between the two groups in family understanding and cooperation,colleagues'understanding and cooperation,and their own cancer awareness scores(P>0.05).In the pretreatment group,before and after chemotherapy,the urine routine,stool routine,urine routine,blood biochemical analysis,electrocardiogram and other indicators did not find fluctuations related to hormone intervention.Conclusion Pretreatment with low-dose dexamethasone before breast cancer surgery can relieve nausea and vomiting caused by chemotherapy,improve the quality of life,and be safe and effective.
作者
王启平
兰安宁
吴晓峰
WANG Qi-ping;LAN An-ning;WU Xiao-feng(Department of Oncology,People's Hospital of Dayu County,Dayu 341500,Jiangxi,China)
出处
《医学信息》
2020年第14期146-148,共3页
Journal of Medical Information
基金
赣州市指导性科技计划项目项目(编号:GZ2019ZSF358)。
关键词
乳腺癌
化疗
地塞米松
多西他赛
Breast cancer
Chemotherapy
Dexamethasone
Docetaxel
