摘要
目的:探讨根据住ICU危重症患者血清降钙素原的水平为其使用抗生素进行治疗的效果。方法:将2014年6月至2018年6月期间在苏州高新区人民医院ICU住院的144例危重症患者随机分为观察组和对照组。两组患者均疑似发生呼吸道细菌感染。对两组患者均进行常规治疗。在此基础上,为对照组患者使用抗生素进行治疗,为观察组患者在血清降钙素原>0.002 mg/L时使用抗生素进行治疗。然后观察两组患者血清C反应蛋白(CRP)的水平、全血白细胞计数(WBC)、使用抗生素的时间、住院的时间及生存情况。结果:治疗后,两组患者血清CRP的水平及全血WBC均有所降低,与治疗前相比,P<0.05。治疗后,两组患者血清CRP的水平及全血WBC相比,P>0.05。治疗后,观察组患者使用抗生素的时间及住院的时间均短于对照组患者,其生存率高于对照组患者,P<0.05。结论:根据住ICU危重症患者血清降钙素原的水平为其使用抗生素进行治疗可获得良好的效果,缩短其使用抗生素的时间及住院的时间,提高其生存率。
Objective:To investigate the therapeutic effect of antibiotics on critically ill ICU patients according to their serum levels of procalcitonin.Methods:144 critically ill patients hospitalized in ICU of People’s Hospital of Suzhou High-tech Zone from June 2018 to June 2014 were randomly divided into observation group and control group.Both groups of patients were suspected to have respiratory tract bacterial infection.Both groups received routine treatment.On this basis,antibiotics were administered to patients in the control group and to patients in the observation group when serum procalcitonin>.002 mg/L.Serum C-reactive protein(CRP)levels,whole blood white blood cell count(WBC),duration of antibiotic use,length of hospital stay,and survival were then observed in both groups.Results:After treatment,serum CRP level and whole blood WBC were decreased in both groups,P<0.05 compared with before treatment.After treatment,the serum CRP level and whole blood WBC of the two groups were compared,and P>0.05.After treatment,the duration of antibiotic use and hospital stay in the observation group were shorter than those in the control group,and the survival rate was higher than that in the control group(P<0.05).Conclusion:Antibiotic therapy based on the level of serum procalcitonin in ICU patients with critical illness can achieve good results,shorten the duration of antibiotic use and hospitalization,and impro ve the survival rate.
作者
焦云
Jiao Yun(Department of Critical Care Medicine,People’s Hospital of Suzhou High-t ech Zone,Suzhou Jiangsu 215010)
关键词
抗生素
血清降钙素原
危重症
住院的时间
Antibiotics
Serum procalcitonin
Critically ill
Length of hospital stay
