摘要
目的评价血清降钙素原对儿科呼吸道感染短程抗菌治疗的指导作用。方法选取2015年3月至2016年3月于广州市增城区人民医院进行诊治的细菌性呼吸道感染患儿124例,随机分为观察组和对照组各62例。观察组患儿运用血清降钙素原指标检测指导治疗,对照组患儿运用常规经验指导治疗,比较两组患儿的治疗效果及抗生素应用情况。结果观察组患儿总有效率为90.32%,对照组患儿为87.10%,两组比较差异无统计学意义(P>0.05)。降钙素原水平随治疗时间的延长不断下降,差异均有统计学意义(t=2.300~22.091,P<0.05);白细胞计数(WBC)值在治疗前五天时变化差异均无统计学意义(均P>0.05),在治疗结束时恢复至正常水平(t=11.413~6.059,均P<0.05);C反应蛋白(CRP)值在治疗第三天时升高,后逐渐下降,差异有统计学意义(t=5.171~17.276,均P<0.05)。观察组患儿抗生素使用时间、住院时间、住院费用均明显低于对照组,差异均有统计学意义(t值分别为4.257、5.286、10.357,均P<0.05)。结论血清降钙素原的动态监测有助于抗生素治疗方案的调整,并对短程抗菌治疗有指导作用。
Objective To evaluate the guiding value of serum procalcitonin in antibiotic therapy of pediatric respiratory tract infection.Methods From March 2015 to March 2016,124 children diagnosed with bacterial respiratory tract infection in People ＇s Hospital of Zengcheng District were selected and randomly divided into observation group and control group（n = 62）. Antibiotic therapy was guided by serum procalcitonin index in the observation group and the control group used conventional experience. Treatment effect and application of antibiotics were compared between two groups. Results Total effective rate of the experimental group and the control group was 90. 32%and 87. 10%,respectively,and the difference was significant（P〈0. 05）. Levels of procalcitonin decreased with course prolonging,and the difference was statistically significant（t value ranged 2. 300 to 22. 091,all P〈0. 05）. The count of WBC did not change significantly at the first 5 days of treatment（all P〈0. 05） and restored to normal level at the end of treatment（t value ranged 11. 413 to 6. 059,all P〈0. 05）. CRP increased at the third day after treatment and then decreased gradually with statistical significance（t value ranged 5. 171 to 17. 276,all P〈0. 05）. Antibiotics use time,length of hospitalization,hospitalization cost of the observation group were significantly lower than the control group（t value was 4. 257,5. 286 and 10. 357,respectively,all P〈0. 05）. Conclusion Dynamic monitoring serum procalcitonin contributes to antibiotic therapy adjustment and has a guiding role on short course of antibiotic therapy.
出处
《中国妇幼健康研究》
2017年第6期650-652,664,共4页
Chinese Journal of Woman and Child Health Research
关键词
血清降钙素原
抗菌治疗
呼吸道感染
儿童
serum procalcitonin
antibiotic therapy
respiratory tract infection
children
