摘要
目的:比较分析不同血供类型的局部晚期乳腺癌(LABC)患者新辅助灌注化疗后序贯外科手术的临床疗效差异。方法:回顾性分析深圳市第二人民医院2003年1月至2008年5月期间乳腺癌外科术前介入新辅助化疗的LABC患者49例,分为乏血供组22例、富血供组27例;均采用多柔比星为主的联合化疗方案,行肿瘤区域动脉灌注化疗,约4~8周后行外科手术治疗。观察两组患者的近期临床疗效、不良反应及中远期临床生存率。结果:灌注化疗结束后至手术前,富血供组所用时间(22.56±5.31)d明显短于乏血供组(33.64±8.70)d,差异具有统计学意义(P<0.05);两组灌注化疗疗程结束后,富血供组肿块大小为(24.73±15.65)cm^2,乏血供组肿块大小为(52.21±15.59)cm^2。富血供组较乏血供组肿块缩小更明显,差异具有统计学意义(P<0.05);生存率方面、富血供组前3年累积生存率与乏血供组相仿,但第5年以后累积生存率富血供组明显好于乏血供组,差异具有统计学意义(P<0.05)。结论:局部晚期乳腺癌患者术前行灌注化疗有良好的临床疗效,且富血供型患者能获得更好的中长期临床生存率。
Objective To compare and analyze the clinical efficacy of neoadjuvant interventional chemotherapy in locally advanced breast cancer patients with different blood supply types.Methods A total of 49 cases of preoperative interventional neoadjuvant chemotherapy for breast cancer in our hospital from January 2003 to May 2008 were reviewed,including 22 cases in the poor blood supply group and 27 cases in the rich blood supply group.All patients were treated with doxorubicin-based combined chemotherapy,followed by arterial infusion chemotherapy in the tumor area,and surgical treatment was performed about 4-8 weeks later.The short-term clinical efficacy,adverse reactions and long-term clinical survival rate of the two groups were observed.Results From the end of interventional chemotherapy to the operation,the time of the rich blood supply group(22.56±5.31)days was significantly shorter than that of the poor blood supply group(33.64±8.70)days(P<0.05).At the end of chemotherapy,the tumor mass size of the two groups was(24.73±15.65)cm^2 in the rich blood donor group and(33.73±21.45)cm^2 in the poor blood donor group.The tumor size in the rich blood supply group was more obvious than that in the poor blood supply group,and the difference was statistically significant(P<0.05).In terms of survival rate,the cumulative survival rate of the rich blood donor group in the first 3 years was similar to that of the poor blood donor group,but the cumulative survival rate of the rich blood donor group was significantly better than that of the poor blood donor group after the 5th year,with significant statistical significance(P<0.05).Conclusion preoperative interventional chemotherapy for locally advanced breast cancer has a good clinical effect,and the patients with rich blood supply can obtain a better medium-and long-term clinical survival rate.
作者
刘春霖
杜端明
洪跃飞
江磊昌
LIU Chun-lin;DU Duan-ming;Hongyue-fei;JIANG Lei-chang(Shenzhen Second People’s Hospital,Guangdong Shenzhen 518035)
出处
《深圳中西医结合杂志》
2020年第12期6-9,F0003,共5页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
深圳市科技研发资金项目资助课题(JCYJ20130329104732074)。
关键词
乳腺癌
灌注化疗
富血供
乏血供
Breast cancer
Perfusion chemotherapy
Rich blood supply
Poor blood supply
