摘要
目的 评价动脉灌注化疗药物治疗乳腺癌病例临床疗效。方法 采用Seldinger法经皮股动脉穿刺 ,将导管置于锁骨下动脉与胸廓内动脉开口交界处的近侧 ,用充气止血带高于患者收缩压阻断患侧肱动脉血流后 ,注入化疗药物 ,根据患者情况 3～ 4周重复灌注化疗。化疗方案 :环磷酰胺 (CTX ) 2 0 0～ 40 0mg/m2 、阿霉素 (ADR )或表阿霉素 (EADR ) 5 0～ 70mg/m2 、5 氟尿嘧啶(5 FU ) 75 0～ 10 0 0mg/m2 、甲酰四氢叶酸钙 (CF) 10 0～ 2 0 0mg。 结果 本组 65例 ,随访 8个月～ 11年 (平均 5 0个月 ) ,CR 4例 ,PR 47例 ,MR 14例 ,总缓解率 (CR +PR) 78.5 % ;11例曾接受全身化疗者 ,PR 8例、MR 3例 ;5例曾行局部放疗者均为PR。结论 动脉内灌注化疗药物对提高乳腺癌的生存率有积极意义 ,且对全身化疗或局部放疗无效果者仍有可能通过动脉灌注取得较好效果。
Objective To evaluate the clinical effect of chemotherapy via regional arterial infusion (CRAI) for breast cancer.Methods Using Seldinger techeque,a catheter was placed on the proximal side of the junction of subclavicular artery and the top of intrathoracicartery via coelicaus.After blocking the brichial artery of the involved side by pneumatic tourniquet chemotherapeutic drugs were instilled.Depending on the patient's situation,the procedure was repeated once 3-4 weeks later.The specific chemotherapeutic plan was as following:CTX 200-400 mg/m 2,ADR or EADR 50～70 mg/m 2,5-FU 750-1?000 mg/m 2,CF 100-200 mg.Results All of the 65 cases were followed up for 8 months to11 years (average 50 months),including 4 cases with CR,47 cases with PR and 14 cases with MR,and the total effective Rate (CR+PR) was 78.5%.Of 11 cases treated with systemic chemotherapy,there were 8 with PR and 5 with MR,while 5 treated with regional radiotherapy were all PR.Conclusion Chemotherapy by artery infusion has significance in raising the survival rate in patients with breast cancer,and satisfactory result can be obtained for the patients treated ineffectively by systemic chemotherapy or regional radiotherapy before.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2004年第5期625-626,共2页
Chinese Journal of Experimental Surgery
