摘要
目的:探讨热性惊厥患儿血清神经元特异性烯醇化酶(NSE)、胶原酸性纤维蛋白(GFAP)、肾上腺髓质素(ADM)的变化及其与患儿神经功能损伤的关系。方法:选取我院诊治的148例热性惊厥患儿(惊厥组)和90例发热未产生惊厥的患儿(非惊厥组),检测对比两组的血清NSE、GFAP、ADM水平,根据患儿动态脑电图结果、不同发作类型将惊厥组进行分层对比血清NSE、GFAP、ADM水平。结果:惊厥组患儿血清NSE、GFAP、ADM水平显著高于非惊厥组;复杂性热性惊厥患儿血清NSE、GFAP、ADM水平显著高于单纯性热性惊厥患儿;经动态脑电图检查,发现62例患儿脑电图异常,86例患儿脑电图正常;脑电图异常患儿血清NSE、GFAP、ADM水平显著高于脑电图正常组患儿,差异具有统计学意义(P<0.05);治疗3 d后,惊厥组患儿血清NSE、GFAP、ADM水平均较治疗前降低且差异具有统计学意义(P<0.05)。结论:热性惊厥患儿血清NSE、GFAP、ADM水平升高,尤其是出现神经功能损伤的患儿,检测上述指标对于判断热性惊厥是否造成患儿神经功能损伤具有一定的参考作用。
Objective:To investigate the relationship between the changes of serum neuron specific enolase(NSE),glial fibrillary acidic protein(GFAP)and adrenomedullin(ADM)and neurological impairment in children with febrile convulsions.Methods:148 cases of febrile convulsions(convulsions group)and 90 cases of febrile children without convulsions(non-convulsions group)in our hospital were selected.Serum NSE,GFAP and ADM levels were compared between the two groups,and the seizure groups were stratified and compared with the levels of serum NSE,GFAP and ADM according to the dynamic electroencephalogram(EEG)results and different convulsion types.Results:The serum NSE,GFAP and ADM levels of children in the convulsions group were significantly higher than those in the non-convulsions group;The serum NSE,GFAP and ADM levels of children with complex febrile convulsions were significantly higher than those with simple febrile convulsions;Through dynamic electroen-cephalogram examination,it was found that 62 children had abnormal EEG,and 86 children had normal EEG;serum NSE,GFAP,ADM levels in children with abnormal EEG were significantly higher than those in normal EEG(P<0.05);After 3 days of treatment,the levels of serum NSE,GFAP and ADM in the convulsions group were lower than before treatment and the difference was statistically significant(P<0.05).Conclusion:Serum NSE,GFAP,and ADM levels are elevated in children with febrile convulsions,especially in children with neurological damage.The detection of these indicators has a certain reference for judging whether febrile convulsions cause neurological impairment in children.
作者
郝改领
徐丽娟
常海霞
张楠
常春荣
张中馥
HAO Gailing;XU Lijuan;CHANG Haixia;ZHANG Nan;CHANG Chunrong;ZHANG Zhongfu(Emergency Department,Hebei Children's Hospital Affiliated to Hebei Medical University,Shijiazhuang 050031,China)
出处
《现代医学》
2020年第4期452-455,共4页
Modern Medical Journal
基金
2018年度河北省医学科学研究重点课题计划(20180614)。
