摘要
目的探讨血府逐瘀汤辅以外用药物治疗黄褐斑并月经不调患者的疗效。方法将110例黄褐斑并月经不调患者随机分为对照组(给予外用药物治疗)与研究组(给予血府逐瘀汤联合外用药物治疗),每组55例。比较2组患者治疗效果。结果治疗后,2组月经不调评分、黄褐斑面积显著低于、小于治疗前,且研究组显著低于、小于对照组(P<0.05)。研究组治疗总有效率为96.36%,显著高于对照组的81.82%(P<0.05)。治疗后2组血管内皮生长因子(VEGF)、表皮生长因子(EGF)水平均显著高于治疗前,且研究组显著高于对照组(P<0.05)。结论对于黄褐斑并月经不调患者,采用血府逐瘀汤辅以外用药物治疗可增强疗效,能够减轻月经不调症状,缩小黄褐斑面积,其机制可能与调节VEGF、EGF水平有关。
Objective To investigate the effect of Xuefu Zhuyu Decoction combined with drugs foRexternal use in treatment of patients with chloasma complicated with irregulaRmenstruation.Methods A total of 110 patients with chloasma and irregulaRmenstruation were selected and randomly divided into control group(treated with drugs foRexternal use)and study group(treated with Xuefu Zhuyu Decoction and drugs foRexternal use),with 55 cases in each group.The therapeutic effect was compared between the two groups.Results AfteRtreatment,the score of irregulaRmenstruation and the area of chloasma in both groups were significantly loweRand smalleRthan those before treatment,and these indexes in study group were significantly loweRthan the control group(P<0.05).The total effective rate of the study group was 96.36%,which was significantly higheRthan 81.82%of the control group(P<0.05).AfteRtreatment,the levels of vasculaRendothelial growth factoR(VEGF)and epidermal growth factoR(EGF)in both groups were significantly higheRthan those before treatment,and the levels of VEGF and EGF in the study group were significantly higheRthan those in the control group(P<0.05).Conclusion FoRpatients with chloasma and irregulaRmenstruation,Xuefu Zhuyu Decoction combined with drugs foRexternal use can enhance the curative effect,alleviate the symptoms of irregulaRmenstruation and reduce the area of chloasma,and its mechanism may be related to the regulation of VEGF and EGF levels.
作者
李艳锋
李苗苗
LI Yanfeng;LI Miaomiao(Department of Traditional Chinese Medicine,Xidian Group Hospital,Xi'an,Shaanxi710077)
出处
《实用临床医药杂志》
CAS
2020年第9期87-89,共3页
Journal of Clinical Medicine in Practice
关键词
黄褐斑
月经不调
血府逐瘀汤
外用药物
血管内皮生长因子
表皮生长因子
chloasma
irregulaRmenstruation
Xuefu Zhuyu Decoction
drugs foRexternal use
vasculaRendothelial growth factor
epidermal growth factor
