摘要
目的:探究血清白细胞介素-6(IL-6)在三阴性乳腺癌中的表达情况以及对三阴性乳腺癌的诊断价值。方法:选取2018年1月~2019年3月于我院接受治疗的122例乳腺癌患者为研究对象,其中57例三阴性乳腺癌患者为观察组,65例非三阴性乳腺癌患者为对照组1。另选同期入院治疗的62例乳腺良性肿瘤患者为对照组2。比较三组患者血清IL-6表达水平;比较观察组患者三阴性乳腺癌组织、乳腺纤维组织以及癌旁组织中IL-6表达情况;比较观察组患者不同病理类型中IL-6的表达情况;使用logistics多因素回归分析探究血清IL-6与三阴性乳腺癌之间的相关性。结果:三组患者IL-6比较发现,观察组含量114.24±13.52pg/mL、对照组1含量76.57±10.33pg/mL、对照组2含量14.05±5.39pg/mL,数据有统计学意义P<0.05。不同组织中IL-6比较发现,三阴性乳腺癌组织中IL-6水平最高,乳腺纤维组织次之,癌旁组织中IL-6表达最少,数据有统计学意义P<0.05。不同病理类型患者IL-6比较发现,肿瘤体积>2cm^3、发生淋巴结转移的患者IL-6水平高于其他患者,数据有统计学意义P<0.05。logistics多因素回归分析发现,血清IL-6与三阴性乳腺癌之间有明显的相关性,是三阴性乳腺癌进展的危险因素(OR=1.442,OR下限=1.123),数据有统计学意义P<0.05。结论:血清IL-6在三阴性乳腺癌患者中表达水平较高,病情越严重的患者IL-6表达水平越高,IL-6与三阴性乳腺癌之间相关性明显,临床诊断三阴性乳腺癌具有良好的价值。
Objective:To investigate the expression of serum interleukin-6(IL-6)in triple-negative breast cancer and its diagnostic value.Methods:122 cases of breast cancer treated in our hospital from January 2018 to March 2019 were selected as the subjects,of which 57 patients with triple-negative breast cancer were observed group and 65 patients with non-triple-negative breast cancer were the control group one.62 patients with benign breast tumors who were selected as control group two.The expression of IL-6 in serum tissues was detected and analyzed in patients with different pathological types.And the correlation between serum IL-6 and triple-negative breast cancer was investigated using logistics multi-factor regression analysis.Results:In three groups of patients,the content of IL-6 was 114.24±13.52pg/mL,control group 1 content 76.57±10.33pg/mL,control group 2 content 14.05±5.39pg/mL,the data were statistically significant P<0.05.The data showed that the highest level of IL-6 in triple-negative breast cancer tissues,followed by breast fiber tissues,and the lowest level of IL-6 was found in paracancerous tissues,with statistical significance(P<0.05).The IL-6 level in patients with tumor volume>2cm^3 and lymph node metastasis was higher than that in other patients(P<0.05).Logistics multi-factor regression analysis showed that there was a significant correlation between serum IL-6 and triple-negative breast cancer,which was a risk factor for the progression of disease(OR=1.442,OR lower limit=1.123,P<0.05).Conclusion:the expression level of serum IL-6 is high in patients with triple-negative breast cancer,and the more serious the disease is,the higher the expression level of IL-6.The correlation is obvious between triple-negative breast cancer and IL-6,which may have diagnostic value for the disease.
作者
申艳飞
SHEN Yan-fei(The third people's Hospital of Anyang City,Henan Province,Henan Anyang 455000)
出处
《医学检验与临床》
2020年第5期10-13,共4页
Medical Laboratory Science and Clinics
关键词
血清IL-6
三阴性乳腺癌
诊断价值
Serum IL-6
Triple-negative breast cancer
Diagnostic value
