摘要
目的了解结肠癌患者围手术期的免疫功能变化,探讨结肠癌组织切除对免疫功能的影响。方法应用流式细胞仪检测33例结肠癌患者手术前后外周血中T淋巴细胞CD69的表达百分率及IL-2的表达水平,并与对照组进行比较分析。结果结肠癌组患者术后第1天CD69表达百分率高于术前(P<0.01),术后第1、3、5、10天CD69表达百分率无明显变化;结肠癌组IL-2的表达水平术后1、3d与对照组相比无变化,第5天IL-2表达水平高于对照组(P<0.05),第10天IL-2表达水平同术前相比明显升高(P<0.01)。结论结肠癌患者术前免疫功能低下,术后活化T细胞明显增多,表明切除肿瘤有利于提高患者的免疫功能,增强机体的抗癌能力,提高机体的自体免疫机能。
Objective To test the change of immunity function after colon cancer operation. Methods Test the activity of CD69 and level of IL-2 by cell flow cytometer after colon cancer operation in 33 cases. Results The activity of CD69 was significantly higher after operation 1 st day compared with nonoperation patients, and the activity of CD69 expression is unchange from the after operation 3 d to 10 d. The level of IL-2 was nondifferent from the first day to third day after operation. The level of IL-2 was higher 5 d after operation than the control group （P 〈 0.05 ）, the level of IL-2 10 d after operation was significantly higher than unoperation group （P 〈 0.01 ）. Conclusion The immunity function is inhibited in colon cancer patients. The ability of anticancer and immunity function is improved after colon cancer operation.
出处
《首都医科大学学报》
CAS
2007年第1期20-22,共3页
Journal of Capital Medical University
