摘要
目的探索乳腺浸润性导管癌中10号染色体同源缺失性磷酸酶-张力蛋白(PTEN)和基质金属蛋白酶诱导因子1(Basigin1)蛋白的表达,并分析其与乳腺浸润性导管癌临床病理学特征及分子亚型的关系。方法回顾性收集郑州人民医院2014年1月至2015年12月期间的76例乳腺原发浸润性导管癌病理活检标本,以及同期的20例乳腺良性增生组织,采用免疫组织化学染色法检测组织中PTEN蛋白和Basigin1蛋白的表达情况,分析其表达与临床病理学特征及分子亚型的关系,以及二者表达的相关性。结果乳腺浸润性导管癌组织中PTEN蛋白的高表达率低于乳腺良性增生组织[56.6%(43/76)比85.0%(17/20),χ2=5.457,P=0.019],而Basigin1蛋白的高表达率高于乳腺良性增生组织[51.3%(39/76)比25.0%(5/20),χ2=4.417,P=0.036]。在乳腺浸润性导管癌组织中,PTEN蛋白的高表达与WHO分级和淋巴结转移状况均相关(P<0.05);Basigin1蛋白的表达与WHO分级、淋巴结转移状况和TNM分期均相关(P<0.05)。PTEN蛋白的高表达与乳腺癌的分子亚型有关(P<0.001),其在Luminal A型和Luminal B型中的高表达率高于Her-2过表达型和基底样亚型;Basigin1蛋白的高表达与乳腺癌的分子亚型也有关(P<0.001),其在Her-2过表达型和基底样亚型中的高表达率高于Luminal A型和Luminal B型。在乳腺浸润性导管癌组织中,PTEN蛋白与Basigin1蛋白的表达呈负相关(rs=–0.481,P<0.001)。结论乳腺浸润性导管癌中可能存在某些机制,使PTEN蛋白和Basigin1蛋白共同促进乳腺癌的发生和发展。
Objective To investigate the expression of phosphate and tension homology deleted on chromsome ten(PTEN) and Basigin1, as well as their relationships with clinicopathological factors and molecular subtypes in invasive ductal carcinoma of breast. Methods The expressions of PTEN and Basigin1 protein were examined in 76 invasive ductal carcinoma of breast tissues by immunohistochemical method, and 20 breast benign hyperplasia tissues as control.These 76 patients underwent surgery in our hospital from Jan. 2014 to Dec. 2015. Results The high-expression rate of PTEN protein in invasive ductal carcinoma of breast tissues was lower than that in benign hyperplasia tissues [56.6%(43/76) vs. 85.0%(17/20), χ2=5.457, P=0.019], while the high-expression rate of Basigin1 protein was higher than that of the benign hyperplasia tissues [51.3%(39/76) vs 25.0%(5/20), χ2=4.417, P=0.036]. The high-expression of PTEN protein was positively correlated with WHO grade and lymph node metastasis status(P<0.05). The high-expression of Basigin1 protein was positively correlated with WHO grade, lymph node metastasis status, and TNM stage(P<0.05). In addition,the high-expression of PTEN protein was associated with molecular subtypes of breast cancer(P<0.001), and its highexpression rate was higher in Luminal A and Luminal B patients;the high-expression of Basigin1 protein was associated with molecular subtypes of breast cancer too(P<0.001), and the high-expression rate of Basigin1 protein was higher in Her-2 overexpression and basal-like subtypes of breast cancer patients. Spearman correlation analysis shown that expression of PTEN protein was negatively correlated with expression of Basigin1 protein(rs=–0.481, P<0.001).Conclusion PTEN and Basigin1 protein may have some mechanisms to promote the occurrence and development of breast cancer, which provide a new basis for targeted treatment of breast cancer.
作者
王建君
徐小艳
冯智坤
杨金花
WANG Jianjun;XU Xiaoyan;FENG Zhikun;YANG Jinhua(Department of Pathology,People’s Hospital of Zhengzhou,Zhengzhou 450000,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2020年第7期825-830,共6页
Chinese Journal of Bases and Clinics In General Surgery
基金
河南省普通科技攻关计划(项目编号:182102311189)。
