摘要
目的探讨加味百合固金汤联合大承气汤对晚期肺癌合并肺炎患者炎症因子的影响。方法将2012年3月-2018年2月本院150例晚期肺癌合并肺炎患者,随机分两组,各75例,对照组采用常规基础治疗;在此基础上,观察组采用加味百合固金汤联合大承气汤治疗,1剂/d,两组患者持续治疗14 d。比较两组患者的临床疗效、降钙素原(Procalcitonin,PCT)、白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)及T淋巴细胞亚群,记录不良反应状况。结果对照组有效率84.00%低于观察组94.67%,差异具有统计学意义(P<0.05)。两组患者不同时间点血清PCT、IL-6、TNF-α及T淋巴细胞亚群比较,差异具有统计学意义(P<0.05)。治疗7 d对照组和观察组PCT为(8.64±3.12)、(6.17±2.57),IL-6为(34.15±10.21)、(25.10±9.85),TNF-α为(136.95±37.85)、(101.06±35.27),CD3^+为(48.31±4.35)、(52.61±4.89),CD8^+为(26.79±2.50)、(25.84±2.35),CD4^+/CD8^+为(1.36±0.16)、(1.46±0.17),治疗14 d对照组和观察组PCT为(5.67±2.41)、(4.10±2.13),IL-6为(23.31±8.10)、(16.53±7.69),TNF-α为(97.41±34.11)、(72.05±28.96),CD3^+为(53.59±5.10)、(57.42±5.31),CD8^+为(25.16±2.41)、(23.45±2.14),CD4^+/CD8^+为(1.45±0.17)、(1.69±0.20),对照组和观察组上述指标比较,差异具有统计学意义(P<0.05)。两组患者不良率比较,差异无统计学意义(P>0.05)。结论加味百合固金汤联合大承气汤对晚期肺癌合并肺炎患者的疗效确切,可以降低炎症因子,提高免疫功能,且患者可以耐受,安全性高。
Objective To investigate the effect of Modified Baihe Gujin Decoction combined with Dachengqi Decoction on inflammatory factors of patients with advanced lung cancer complicated with pneumonia.Methods Totally 150 patients with advanced lung cancer complicated with pneumonia in our hospital from March 2012 to February 2018 were randomly divided into two groups,75 cases in each group.The control group was treated with routine basic treatment and the observation group was treated with Modified Baihe Gujin Decoction combined with Dachengqi Decoction,one dose a day,and the two groups were treated continuously for 14 days.The clinical efficacy,procalcitonin(PCT),interleukin-6(IL6),tumor necrosis factor-alpha(TNF-alpha)and T lymphocyte subsets were compared between the two groups,and the adverse reactions were recorded.Results The effective rate of the control group(84.00%)was lower than the observation group(94.67%)(P<0.05).There were significant differences in serum levels of PCT,IL-6,TNF-alpha and T lymphocyte subsets between the two groups at different time points(P<0.05).Seven days after treatment,PCT levels of the control group and observation group were(8.64±3.12)ng/mL and(6.17±2.57)ng/mL.IL-6 levels were(34.15±10.21)pg/mL and(25.10±9.85)pg/mL.TNF-αlevels were(136.95±37.85)ng/mL and(101.06±35.27)ng/mL.CD3^+percentages were(48.31±4.35)%and(52.61±4.89)%.CD8^+percentages were(26.79±2.50)%and(25.84±2.35)%.The rations of CD4^+/CD8^+were1.36±0.16 and 1.46±0.17.Fourteen days aftertreatment,PCT levels of the control group and observation group(5.67±2.41)ng/mL and(4.10±2.13)ng/mL.IL-6 levels were(23.31±8.10)pg/mL and(16.53±7.69)pg/mL.TNF-αlevels were(97.41±34.11)ng/mL and(72.05±28.96)ng/mL.CD3^+percentages were(53.59±5.10)%and(57.42±5.31)%.CD8^+percentages were(25.16±2.41)%and(23.45±2.14)%.The rations of CD4^+/CD8^+were 1.45±0.17 and 1.69±0.20.All indexes in two groups had significant differences(P<0.05).There was no significant difference in the adverse rate between the two groups(P>0.05).Conclu
作者
李昊
LI Hao(Department of Integrated Traditional Chinese and Western Medicine,Tianjin Occupational Disease Prevention and Control Hospital,Tianjin 300011,China)
出处
《辽宁中医杂志》
CAS
2020年第4期101-104,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
天津市科技计划项目(13022)。
关键词
加味百合固金汤
大承气汤
晚期肺癌
肺炎
炎症因子
免疫功能
Modified Baihe Gujin Decoction
Dachengqi Decoction
advanced lung cancer
pneumonia
inflammatory factor
immune function
