摘要
目的观察中西医结合综合方法治疗强直性脊柱炎(Ankylosing Spondylitis,AS)肾虚督寒证的临床疗效及治疗安全性。方法收集2016年3月—2018年11月期间收治的80例强直性脊柱炎肾虚督寒证患者,利用随机数字表法将其分为对照组、观察组各40例,对照组予以美洛昔康片、柳氮磺吡啶片口服治疗;观察组在对照组基础上予以独活寄生汤加减,联合功能训练、腱端炎痛点埋针、中药熏蒸等治疗,疗程3个月。对两组进行中医证候评分、运用疗效评价因子[由国际脊柱关节病协会(ASAS)制定]、记录不良反应发生情况对疗效及安全性进行评估。结果治疗前两组的基本资料、中医证候评分情况、ASAS疗效评价因子及相关指标对比无显著性差异,可进行临床比较。治疗前后进行比较,两组患者每项临床观察指标均有不同程度改善,差异显著(P<0.05)。治疗后两组间对比,观察组患者中医证候评分结果、晨僵时间、患者疾病总体评价指数等方面的改善程度均明显优于对照组患者,差异显著(P<0.05)。治疗过程中所有研究对象均未发生严重不良反应。结论中西医结合综合方法治疗肾虚督寒型强直性脊柱炎可明显提高临床疗效,具有较高的安全性,中医证候疗效明显优于常规口服西药治疗。
Objective To observe the clinical efficacy and treatment safety of integrated traditional Chinese and Western medicine in the treatment of ankylosing spondylitis(kidney deficiency and Du cold syndrome).Methods Eighty patients with ankylosing spondylitis(kidney deficiency and Du cold syndrome)were enrolled in the rheumatology department of our hospital from March 2016 to November 1818.They were randomly divided into the control group and the observation group by 40 cases.The control group received oral administration of meloxicam tablets and sulfasalazine tablets;On the basis of the control group,the observation group was treated with the addition of live-active parasitic soup,combined with functional training,sputum pain points,and Chinese medicine fumigation.The course of treatment was 3 months.The TCM syndrome scores were used for the two groups,and the efficacy evaluation factors[developed by the International Association of Spinal Joint Diseases(ASAS)]were recorded.The incidence and adverse events were evaluated for efficacy and safety.Results There was no significant differences in the basic data,TCM syndrome scores,ASAS efficacy evaluation factors and related indicators between the two groups before treatment,which can be compared clinically.Before and after treatment,each clinical observation index of the two groups of patients improved to different degrees,the difference was significant(P<0.05).After treatment,the improvement of TCM syndrome scores,morning stiffness time,and overall disease evaluation index of the observation group were significantly better than those of the control group,and the difference was significant(P<0.05).No serious adverse reactions occurred in all subjects during the treatment.Conclusion The comprehensive method of integrated traditional Chinese and Western medicine for treating kidney deficiency and Du cold type ankylosing spondylitis can significantly improve the clinical efficacy,and has high safety.The curative effect of TCM syndrome is obviously better than that of convent
作者
王丹
WANG Dan(Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)
出处
《辽宁中医药大学学报》
CAS
2020年第5期95-99,共5页
Journal of Liaoning University of Traditional Chinese Medicine
基金
辽宁省科学计划(18-013-2-13)。
关键词
中西医结合
独活寄生汤
肾虚督寒型
强直性脊柱炎
中药熏蒸
埋针
integrated Chinese and Western medicine
Duhuo Jisheng Decoction
kidney deficiency and Du cold syndrome
ankylosing spondylitis
Chinese medicine fumigation
imbedding needle
