摘要
目的对比不同剂量纳洛酮治疗COP(一氧化碳中毒)对患者预后的影响。方法回顾性研究2018年7月-2019年10月郑州大学附属洛阳中心医院收治的80例COP患者,以随机数字表法分为两组(每组40例):参照组给予0.01mg/(kg·min)纳洛酮治疗,试验组给予0.04mg/(kg·min)纳洛酮治疗,对比两组临床疗效、MMSE评分、催醒时间、迟发性脑病发生率。结果试验组临床总有效率95.00%显著比参照组75.00%高,试验组治疗后MMSE评分显著比参照组高,试验组催醒时间显著比参照组短,试验组迟发性脑病发生率2.50%显著比参照组17.50%低,差异显著(P<0.05)。结论COP患者采纳大剂量纳洛酮治疗,可有效减轻患者临床症状,促进意识恢复,降低迟发性脑病发生率。
Objective To compare the effect of different doses of naloxone on the prognosis of COP(carbon monoxide poisoning)patients.Methods A retrospective study was conducted on 80 patients with COP admitted to the Zhengzhou university luoyang central hospital from July 2018 to October 2019.The patients were randomly divided into two groups(40 patients in each group):the control group was treated with 0.01 mg(kg·min)naloxone,the experimental group was treated with 0.04 mg(kg·min)naloxone.The clinical effect,MMSE score,awakening time and incidence of delayed encephalopathy were compared between the two groups.Results The total effective rate of 95.00%in the test group was significantly higher than that of 75.00%in the control group,the MMSE score of the test group was significantly higher than that of the control group,and the awakening time of the test group was significantly shorter than that of the control group,the incidence of delayed encephalopathy in the experimental group was significantly lower than that in the control group(2.50%vs17.50%,P<0.05).Conclusion High-dose naloxone can effectively relieve the clinical symptoms,promote consciousness recovery and reduce the incidence of delayed encephalopathy in COP patients.
作者
智炎伟
ZHI Yanwei(Department of Pharmacy,Luoyang Central Hospital,Zhengzhou University,Luoyang Henan 471000,China)
出处
《临床研究》
2020年第8期30-31,共2页
Clinical Research
关键词
不同剂量
纳洛酮
一氧化碳中毒
临床疗效
迟发性脑病
different doses
naloxone
carbon monoxide poisoning
clinical efficacy
delayed encephalopathy
