摘要
目的观察雷珠单抗治疗息肉状脉络膜血管病变的临床效果。方法选取澄迈县人民医院眼科2015年6月至2018年12月收治的118例息肉状脉络膜血管病变患者作为研究对象,按照患者患眼息肉数分为单息肉组(A组)和多息肉组(B组),各59例。两组患者均给予雷珠单抗治疗,对比两组的最佳矫正视力、中心视网膜厚度和临床治疗有效率。结果治疗后,A组最佳视力矫正程度明显低于B组,且A组随着术后时间的延长,视力矫正有下降趋势(P<0.05);治疗后1、2、3个月,A组中心视网膜厚度低于B组,两组均呈先下降再上升的趋势;B组治疗总有效率为91.5%,明显高于A组的76.3%,差异有统计学意义(P<0.05)。结论雷珠单抗对多息肉状脉络膜血管病变患者的最佳视力矫正较好,且治疗有效率较高,而对单息肉状脉络膜血管病变患者的中心视网膜厚度恢复程度较好,因此,临床应结合患者的病情选择适合的治疗方式。
Objective To observe the clinical effect of ranibizumab in the treatment of polypoidal choroidal vasculopathy. Methods 118 patients with polypoidal choroidal vascular disease who were admitted to the Department of Ophthalmology of Chengmai County People’ s Hospital from June 2015 to December 2018 were selected as the research subjects.According to the number of eye polyps, patients were divided into single polyp group(group A) and multiple polyp group(group B), with 59 cases in each group. The patients in both groups were treated with ranibizumab,and the best corrected visual acuity, central retinal thickness and clinical treatment efficiency of the two groups were compared. Results After treatment, the best degree of vision correction in group A was significantly lower than that in group B, and with the prolongation of postoperative time in group A, vision correction showed downward trend(P<0.05). At 1 month, 2 months and 3 months after treatment, the central retinal thickness in group A was lower than that in group B, and the changes in both groups showed A trend of first decreasing and then increasing. The effective rate of treatment in group B was 91.5%, significantly higher than 76.3% in group A, the difference between the two groups was statistically significant(P<0.05). Conclusion The best visual acuity correction of ranibizumab in patients with polypoidal choroidal vasculopathy is better, and the treatment efficiency is higher, while the recovery of the central retinal thickness is better in patients with single polypoidal choroidal vascular disease, so the clinical should choose a suitable treatment method according to the patient’ s condition.
作者
陈奕富
郑海生
黄承东
陈君
Chen Yifu;Zheng Haisheng;Huang Chengdong;Chen Jun(Department of Ophthalmology,Chengmai County People's Hospital,Haikou,Hainan,571900,China;Hainan Eye Hospital,Sun Yat-sen Eye Center,Sun Yat-sen University,Haikou,Hainan,570311,China)
出处
《当代医学》
2020年第21期47-49,共3页
Contemporary Medicine
