摘要
炎症性肠病(IBD)是一类肠道慢性非特异性炎症性疾病,主要包括溃疡性结肠炎和克罗恩病。IBD患者除消化道症状外,常合并其他肠外表现,可累及骨骼肌肉、皮肤、眼部、肝胆、胰腺、神经、泌尿生殖、肺部、心脏、血液等多系统。胆系疾病是IBD的肠外表现之一,主要包括原发性硬化性胆管炎、IgG4相关性硬化性胆管炎、原发性胆汁性胆管炎、胆石症等。胆系疾病可表现为无症状患者一过性肝功能异常,也可能是威胁生命的肝衰竭,但不同的胆系疾病治疗及预后大有不同,需仔细鉴别诊断。就IBD合并胆系疾病进行评述,以期帮助临床医师熟悉IBD患者胆系疾病的临床表现及诊治策略。
Inflammatory bowel disease(IBD)is a series of non-specific chronic inflammatory diseases,including ulcerative colitis and Crohn’s disease.Besides gastrointestinal symptoms,IBD patients often have extraintestinal symptoms which may involve various systems such as the skeleton and muscle,skin,eyes,liver and gallbladder,pancreas,nerves,urogenital system,lungs,heart,and blood.Biliary diseases are extraintestinal manifestations of IBD and mainly include primary sclerosing cholangitis,IgG4-associated sclerosing cholangitis,primary biliary cirrhosis,and cholelithiasis.Biliary diseases may manifest as transient abnormal liver function in asymptomatic patients and even life-threatening liver failure,and different biliary diseases may have different treatment methods and prognoses and thus require careful differential diagnosis.This article reviews biliary diseases in IBD patients,in order to help clinicians get familiar with the clinical manifestations and diagnosis and treatment strategies for biliary diseases in IBD patients.
作者
刘芸
刘玉兰
LIU Yun;LIU Yulan(Department of Gastroenterology,Peking University People’s Hospital,Beijing 100044,China;Clinical Center of Immune-mediated Digestive Diseases,Peking University People’s Hospital,Beijing 100044,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第7期1450-1453,共4页
Journal of Clinical Hepatology
关键词
炎症性肠病
肝硬化
胆汁性
胆管炎
硬化性
诊断
治疗学
inflammatory bowel disease
liver cirrhosis
biliary
cholangitis
sclerosing
diagnosis
therapeutics
