摘要
目的探讨甲强龙耳后及鼓室注射给药对伴糖尿病的突发性聋患者的疗效及不良反应。方法回顾性分析2013年10月至2018年9月经廊坊市第四人民医院耳鼻咽喉科确诊并治疗的伴2型糖尿病的98例突发性聋患者的临床资料,根据甲强龙局部给药途径的不同将所有病例分为耳后组(40例,耳后注射甲强龙40μg/次,隔日一次,共注射5次)和鼓室组(48例,鼓室注射甲强龙40μg/次,隔日一次,共注射5次),两组同时给予相同的常规治疗(给予改善微循环、溶栓、神经营养药物)。观察比较两组疗效、不同频率听阈下降值、伴随症状改善率、并发症。结果①耳后组及鼓室组治疗总有效率分别为75.0%(30/40)、70.8%(34/48),差异无统计学意义(P>0.05)。②两组治疗后不同频率听阈均有下降,以中低频下降幅度较大,但两组之间差异无统计学意义(P>0.05)。③两组治疗后眩晕、耳鸣、耳闷塞感等伴随症状均有改善,但两组间改善率无统计学差异(P>0.05)。④鼓室组局部疼痛、头晕的发生率高于耳后组(P<0.05)。结论甲强龙耳后及鼓室注射均可有效改善伴糖尿病突聋患者的听力及伴随症状,疗效接近,但与鼓室注射相比,耳后注射并发症较少。
Objective To investigate the efficacy of postauricular and transtympanic injection of methylprednisolone for sudden deafness(SD) with type-2 diabetes.Methods The clinic data of 98 SD patients with type-2 diabetes in our hospital from October 2013 to September 2018 were reviewed retrospectively. All patients were divided into postauricular group(postauricular injection, n=40)and transtympanic group(transtympanic injection,n=48).The curative effect, the rate of improvement of symptoms and the complications were observed and compared in the two groups.Results ①The total effective rate of treatment in postauricular group and transtympanic group was 75.0% and 70.8% respectively, and the difference was not statistically significant(P>0.05).②After treatment, the auditory threshold of different frequencies decreased in the two groups, while the range of medium and low frequency decreased significantly, but the difference was not statistically significant between the two groups(P>0.05).③The associated symptoms of vertigo, tinnitus and earnuts were improved after treatment in two groups, but there was no statistical difference in the improvement rate between the two groups(P>0.05).④The incidence of local pain and dizziness in transtympanic group was higher than that in postauricular group(P<0.05).Conclusion Both postauricular injection and transtympanic injection were effective in improving the hearing and associated symptoms of SD patients with type-2 diabetes,but postauricular injection has few complications compared with transtympanic injection.
作者
朱艳香
刘文彬
陈菲
宋广朴
谢微
Zhu Yanxiang;Liu Wenbin;Chen Fei;Song Guangpiao;Xie Wei(Otolaryngology Department,Fourth People’s Hospital of Langfang City,Langfang,065700,China;不详)
出处
《听力学及言语疾病杂志》
CAS
CSCD
北大核心
2020年第4期383-386,共4页
Journal of Audiology and Speech Pathology
基金
廊坊市科学技术研究与发展计划(2018013043)。
关键词
甲强龙
突发性聋
耳后注射
鼓室注射
2型糖尿病
Methylprednisolone
Sudden deafness
Postauricular injection
Transtympanic injection
Type-2 diabetes
