摘要
目的 定量评价25-羟维生素D水平与冠心病之间的关系.方法 通过知网、万方、维普等国内大型数据库检索,并通过严格的质量控制筛选、去重,最终纳入15篇25-羟维生素D水平与冠心病关系的定量研究.采用Meta分析方法,应用Stata 15.0软件进行数据处理,并进行发表偏倚及敏感性分析.结果 随机效应Meta分析结果显示:冠心病组维生素D水平低于对照组(P<0.05),WMD=-20.05,95%CI=(-25.56,-14.55).存在发表偏倚,但通过剪补法评估发表偏倚后,发现本研究发表偏倚小,表明结论 是稳健的.结论 冠心病患者体内25-羟维生素D水平明显低于正常人,提示可通过补充维生素D降低冠心病的发病率.
Objective To quantitatively evaluate the relationship between 25-hydroxyvitamin D level and coronary heart disease.Methods 15 quantitative studies on the relationship between 25-hydroxyvitamin D level and coronary heart disease were included through searching large domestic databases such as CNKI,Wanfang and Weipu,screening by strict quality control.Stata 15.0 software was used to do the meta-analysis including data processing,publication bias evaluation and sensitivity analysis.Results The results of meta-analysis showed that the level of vitamin D in CHD group was lower than that in control group(P<0.05),WMD=-20.05,95%CI=(-25.56,-14.55).Publication bias exists,but after evaluating publication bias by trim and filling method,it is found that publication bias of this study is small,indicating that the conclusion is reliable.Conclusion The level of 25-hydroxyvitamin D in patients with coronary heart disease is significantly lower than that in normal people,suggesting that the incidence of coronary heart disease can be reduced by vitamin D supplementation.
作者
史斌浩
王建飞
Shi Binhao;Wang Jianfei(Department of Cardiology,Anhui No.2 Provincial People's Hospital,Hefei,Anhui,230041,China)
出处
《当代医学》
2020年第20期6-9,共4页
Contemporary Medicine
