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冠状动脉粥样硬化性心脏病患者体内维生素D水平变化的研究 被引量:11

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摘要 目的探讨冠状动脉粥样硬化性心脏病(CHD)患者体内维生素D的水平变化及其与冠状动脉病变严重程度的关系。方法选取2014年9月至2015年9月在该院就诊的经冠状动脉造影检查确诊为CHD的患者150例,其中不稳定型心绞痛(UAP)、稳定型心绞痛(SAP)和急性心肌梗死(AMI)患者各50例,同时选取对照组50例。对所有入选对象进行冠状动脉Gensini评分,同时采集股/桡动脉外周血测定血清25-(OH)D3水平。分析CHD组和对照组,以及CHD各亚型组患者的25-(OH)D3水平和Gensini评分。结果 CHD组患者血清25-(OH)D3水平明显低于对照组(t=8.65,P<0.05),而其Gensini评分显著大于对照组(t=42.47,P<0.05)。各亚型组患者血清25-(OH)D3水平和Gensini评分均存在显著性差异,其中SAP组患者血清25-(OH)D3水平最高,UAP组次之,AMI组最低(F=13.70,P<0.05);而AMI组患者Gensini评分最大,UAP组次之,SAP组最小(F=55.64,P<0.05)。CHD患者血清25-(OH)D3水平与Gensini评分呈负相关(r=-0.55,P<0.05)。结论血清维生素D水平过低很有可能是CHD的危险因素。
出处 《重庆医学》 CAS 北大核心 2016年第16期2250-2251,共2页 Chongqing medicine
基金 重庆市大足区科委课题(DZKT.2014ACC1019)
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参考文献14

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二级参考文献23

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