摘要
目的探讨阿立哌唑联合作业疗法治疗精神分裂症伴抑郁患者的临床疗效。方法选取2018年2月至2019年3月于辽宁省朝阳市康宁医院接受治疗的精神分裂症伴抑郁患者84例作为研究对象,按治疗方案不同分为对照组(常规精神科药物,42例)与观察组(常规精神科药物+阿立哌唑+作业疗法,42例)。比较两组治疗前、治疗4周后阳性与阴性症状量表(PANSS)评分及血清脑源性神经营养因子(BDNF)、胶质细胞源性神经营养因子(GDNF)、5-羟色胺1A(5-HT1A),评估两组患者治疗前及治疗4周后认知功能情况。结果治疗后两组阳性症状、阴性症状及精神病理评分降低,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组患者的BDNF、GDNF、5-HT1A水平升高,且观察组血清BDNF、GDNF、5-HT1A水平明显高于对照组,差异有统计学意义(P<0.05);两组患者治疗后蒙特利尔认知评估量表(Mo CA)评分升高,且观察组患者Mo CA评分明显高于对照组,差异有统计学意义(P<0.05)。结论阿立哌唑联合作业疗法治疗精神分裂症伴抑郁患者效果显著,利于降低PANSS评分,改善血清BDNF、GDNF、5-HT1A水平,提高认知功能。
Objective To investigate the effects of aripiprazole combined with occupational therapy in the treatment of patients with schizophrenia and depression.Methods A total of 84 patients with schizophrenia complicated with depression treated in Kangning Hospital of Chaoyang in Liaoning Province from February 2018 to March 2019 were selected as the research subjects,and were divided into a control group(conventional psychiatric drugs,42 cases)and an observation group(conventional psychiatric drugs+aripiprazole+occupational therapy,42 cases)according to different treatment options.The positive and negative symptom scale(PANSS)scores,serum brain-derived neurotrophic factor(BDNF),glial cell-derived neurotrophic factor(GDNF),serotonin 1 A(5-HT1 A)are compared to assess the cognitive function of the 2 groups of patients before treatment and after 4 weeks of treatment.Results After treatment,the positive symptoms,negative symptoms and psychopathology scores of the 2 groups were decreased,and the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the BDNF,GDNF,5-HT1 A level of the 2 groups increased,but the improvement range of the observation group was more obvious,and the difference was statistically significant(P<0.05).The montreal cognitive assessment scale(MoCA)score of the 2 groups of patients increased after treatment,and the MoCA score of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Aripiprazole combined with occupational therapy is effective in the treatment of schizophrenia with depression,which is beneficial to reduce PANSS score,improve serum BDNF,GDNF and 5-HT levels,and improve cognitive function.
作者
赵建君
ZHAO Jian-Jun(Kangning Hospital of Chaoyang City in Liaoning Province,Chaoyang 122000,China)
出处
《中国药物经济学》
2020年第5期98-100,共3页
China Journal of Pharmaceutical Economics
关键词
精神分裂症
抑郁
阿立哌唑
作业疗法
阳性与阴性症状量表
Schizophrenia
Depression
Arisperidone
Operation therapy
Positive and negative symptom scale
