摘要
沸石咪唑酯骨架材料(Zeolitic Imidazolate Framework-8, ZIF-8)是由锌离子与2-甲基咪唑配位自组装成的多孔结晶材料,其比表面积大、孔隙率高、合成便捷、尺寸可控,在功能物质的包封与输运中具有突出的优势。与此同时,这类材料更具备优异的生物相容性,且其结构在生理条件下具有良好的稳定性,而在酸性条件下解体,对于与恶性肿瘤等多种疾病相关的弱酸性环境具有响应性,是控制药物运输与释放的理想载体,因而在生物医学上有很大的应用潜力。事实上,ZIF-8不但能高效负载阿霉素、5-氟尿嘧啶等小分子化疗药物,而且可以充当抗体、核酸等生物大分子的保护层。ZIF-8的粒径等性能对于相应的生物医学应用非常关键,而如何实现ZIF-8功能性的精准调控将是实现其生物医学应用的重要挑战,基于此,本文就ZIF-8的制备机理、性能调控及其生物医学应用进行综述和展望。
Zeolitic imidazolate framework-8(ZIF-8) is a class of porous crystalline materials formed by the self-assembly of zinc ions and 2-methylimidazole. It shows potential advantages in encapsulation and transportation of functional materials owing to its high porosity, large specific surface,convenient synthesis and controllable size. More importantly, ZIF-8 is an ideal carrier for drug delivery and release due to its excellent biocompatibility, stability under physiological conditions and responsiveness to the weak acidic environment associated with malignant tumors and other diseases. In fact, the small molecular drugs(doxorubicin, 5-fluorouracil) and biological macromolecules(antibody, nuclein) have all been loaded into ZIF-8 for chemotherapy, photothermal therapy, photodynamic therapy and biosensing. The particle size of ZIF-8 is very important for biomedical applications, and accurate functional regulation of ZIF-8 is agreat challenge for its biomedical application. Herein, we review the synthesis methods, size-control and biomedicalapplications of ZIF-8.
作者
胡强强
郭和泽
窦红静
Qiangqiang Hu;Heze Guo;Hongjing Dou(School of Materials Science and Engineering,State Key Laboratory of Metal Matrix Composites,Shanghai JiaoTong University,Shanghai 200240,China)
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2020年第5期656-664,共9页
Progress in Chemistry
基金
国家自然科学基金项目(No.21871180)
上海市“科技创新行动计划”基础研究领域项目(No.18JC1413500)
上海高校特聘教授(东方学者)计划(No.SHDP201802)
上海市教委“曙光计划”(No.12SG12)资助。
关键词
ZIF-8
合成机理
粒径调控
弱酸性环境敏感
生物医学应用
ZIF-8
synthetic mechanism
size control
acidic environmental responsivity
biomedical application
