摘要
目的:探讨雷尼酸锶(strontium ranelate,SR)对去卵巢骨质疏松大鼠植入性假体的骨整合效果。方法:选取SD雌性大鼠30只,分为治疗组(15只)和对照组(15只),将钛合金植入双侧卵巢切除骨质疏松大鼠模型的胫骨结节处。治疗组每天给予雷尼酸锶400 mg/kg灌胃,对照组给予同等剂量生理盐水灌胃,持续12周后处死大鼠并取材,进行组织力学测试及组织学观察。结果:SR灌胃组的植入假体的推出压力及剪切强度均高于对照组,差异有统计学意义(P<0.05)。治疗组与对照组相比,植入物周围纤维界膜稀少且薄,新生骨较多,且与植入体界面多为直接骨性接触,对照组骨质疏松大鼠植入假体周围软组织界膜的面积和厚度高于治疗组,差异有统计学意义(P<0.01)。结论:SR经胃肠给药可有效提高骨质疏松大鼠植入假体的骨整合。
Objective:To explore the impact of strontium ranelate(SR)to prosthesis osseointegration in osteoporotic rats.Methods:Thirty SD female rats were divided into two groups randomly,the control group and the treatment group(15 in each group).The osteoporotic animal model was made by ovariectomy.After the establishment of the model,titanium alloy prosthesis was placed on the vertical bone surface of bilateral tibial tubercle.The treatment group received strontium ranelate 400 mg/kg gavage everyday,and the control group received the same dose of normal saline gavage for 12 weeks.Then rats were sacrificed for histological observation and histomorphometric determination.Results:In the treatment group the pressure and shear strength of prosthesis implant were significantly different from that in the control group.Compared with the control group,the fibrous membrane around the prosthesis in the treatment group was sparse and thin,and the new bone was more,and the interface with the prosthesis was mostly in direct contact.Histomorphometry showed that in the control group periprosthetic membrane thickness and area were significantly higher than in the treatment group,the difference was significant(P<0.01).Conclusions:SR via gastrointestinal has certain role in promoting prosthesis osseointegration of osteoporotic rats.
作者
田波
王加冕
刘宇一
马易群
王会仁
林红
TIAN Bo;WANG Jia-mian;LIU Yu-yi;MA Yi-qun;WANG Hui-ren;LIN Hong(Department of Orthopaedics, Zhongshan Hospital, Fudan University, Shanghai 200032, China;College of Medicine, Yanbian University, Yanji 133002, Jilin, China)
出处
《中国临床医学》
2020年第3期433-437,共5页
Chinese Journal of Clinical Medicine
基金
上海市科学技术委员会“扬帆计划”项目(18YF1404400)
上海市科学技术委员会项目(17DZ1920204)
复旦大学附属中山医院科研启动基金(科研基金-267).
关键词
雷尼酸锶
骨质疏松
骨植入物
strontium ranelate
osteoporosis
bone implant
