摘要
目的探讨尼可刹米辅助治疗COPD急性加重期并呼吸衰竭的效果。方法对该院2017年3月-2019年7月收治的COPD急性加重期并呼吸衰竭的患者,按标准从中选择72例作为该次研究的对象,盲选法随机分为两组,各组36例。对照组患者采用无创正压通气治疗,试验组仅仅给予应用尼可刹米辅助治疗。观察与比较两组患者血气指标、住院时间、气管插管情况、治疗总有效率以及不良反应发生情况。结果治疗后试验组患者PaO2(82.79±7.26)mmHg、PaCO2(48.28±6.27)mmHg均优于对照组(75.61±7.23)mmHg、(63.81±6.36)mmHg,差异有统计学意义(t=3.892、4.051,P<0.05)。试验组住院时间(7.92±1.07)d短于对照组(11.53±1.03)d,差异有统计学意义(P<0.05);气管插管率(5.56%)低于对照组25.00%,差异有统计学意义(χ^2=6.027,P<0.05);实验组治疗总有效率(88.89%)高于对照组69.44%,不良发生率5.56%低于对照组22.22%,差异有统计学意义(χ^2=7.305、5.062,P<0.05)。结论对COPD急性加重期合并呼吸衰竭的患者采用尼克刹米治疗可以缩短患者的住院时间,改善患者血气指标,治疗疗效与安全性更高。
Objective To investigate the effect of nicoxamib in the treatment of acute exacerbation of COPD and respiratory failure.Methods For patients with acute exacerbation of COPD and respiratory failure who were treated in our hospital from March 2017 to July 2019,72 patients were selected as the object of this study according to the standard.The blind selection method was randomly divided into two groups,each group 36 cases.Patients in the control group were treated with non-invasive positive pressure ventilation,while the test group was only given adjuvant therapy with nicosamide.Observation and comparison of blood gas index,length of hospital stay,tracheal intubation,total effective rate of treatment,and occurrence of adverse reactions in the two groups of patients.Results PaO2(82.79±7.26)mmHg and PaCO2(48.28±6.27)mmHg in the experimental group were better than those in the control group(75.61±7.23)mmHg and(63.81±6.36)mmHg after treatment,and the differences were statistically significant(t=3.892,4.051,P<0.05).The length of hospital stay in the test group(7.92±1.07)d was shorter than that in the control group(11.53±1.03)d,with the difference was statistically significant(P<0.05);the tracheal intubation rate(5.56%)was lower than the control group by 25.00%,with statistics significance(χ^2=6.027,P<0.05);the total effective rate of treatment in the experimental group(88.89%)was higher than the control group at 69.44%,and the incidence of adverse effects was 5.56%lower than the control group at 22.22%,with significant difference(χ^2=7.305,5.062,P<0.05).Conclusion The treatment of patients with acute exacerbation of COPD with respiratory failure can reduce the length of hospital stay,improve the blood gas index,and improve the efficacy and safety of treatment.
作者
蒋洁
JIANG Jie(Department of Respiratory Medicine,Guangrao County People's Hospital,Guangrao,Shandong Province,251300 China)
出处
《系统医学》
2020年第9期10-12,共3页
Systems Medicine
关键词
慢性阻塞性肺病
呼吸衰竭
尼可刹米
无创正压通气
Chronic obstructive pulmonary disease
Respiratory failure
Nicosameter
Noninvasive positive pressure ventilation
