摘要
内质网应激(ERS)是一种重要的信号反应通路,属于细胞自我保护机制。ERS时,首先启动生存途径——未折叠蛋白反应(UPR),而长时间的ERS将会启动细胞凋亡途径。肝脏组织中包含着丰富的内质网结构,肝脏缺血再灌注损伤(HIRI)时,低氧、缺血、氧化应激等因素会引起ERS。近年来研究发现,ERS与HIRI关系密切,并且适宜的ERS对HIRI有一定的保护作用,还与肝纤维化、病毒性肝炎等疾病有关,进一步研究ERS机制,将为临床工作中肝病的治疗提供新方向。
Endoplasmic reticulum stress(ERS)is an important signaling reaction pathway,which belongs to the mechanism of cell self-protection.In ERS,the survival way-unfolded protein response(UPR)is initially started,and the long time ERS will initiate the apoptotic pathway.There are abundant endoplasmic reticulum(ER)structures in liver tissue.In the hepatic ischemia-reperfusion injury(HIRI),hypoxia,ischemia,oxidative stress and other factors can cause ERS.Recent studies have found that ERS is closely related to hepatic ischemia-reperfusion injury,and the appropriate ERS has a certain protective effect on HIRI.It is also associated with liver fibrosis,viral hepatitis and other diseases,the further study on ERS mechanism will provide a new direction for the treatment of liver diseases in the future clinical work.
作者
潘宁波(综述)
张旭阳
杨龙灿
余曦
张莹(审校)
PAN Ningbo;ZHANG Xuyang;YANG Longcan;YU Xi;ZHANG Ying(Department of Hepatobiliary Surgery,Guizhou Provincial People′s Hospital,Guiyang,Guizhou 550000,China;The Graduate School,Zunyi Medical University,Zunyi,Guizhou 563000,China;Department of Hepatobiliary Surgery,Tongren Municipal People′s Hospital,Tongren,Guizhou 554300,China;Department of Emergency Surgery,Guizhou Provincial People′s Hospital,Guiyang,Guizhou 550000,China)
出处
《重庆医学》
CAS
2020年第12期2029-2033,共5页
Chongqing medicine
基金
贵州省留学人员科技创新项目(黔人项目资助合同[2016]21号)
贵州省科技计划项目(黔科基础[2016]1088)
贵州省卫生计生委科学技术基金(gzwjkj2018-1-046)。
关键词
内质网应激
肝脏缺血再灌注损伤
未折叠蛋白反应
endoplasmic reticulum stress
hepatic ischemia-reperfusion injury
unfolded protein response
