摘要
目的探讨血清胱抑素C(Cys-C)、β2-微球蛋白(β2-MG)及尿微量白蛋白(mALB)水平与妊娠期高血压疾病(HDCP)不良结局的相关性。方法将收治的126例HDCP患者纳入研究,根据其疾病进展程度,分为子痫前期组(PE)48例和妊娠期高血压组(HP)78例,另选同期进行产检的健康孕产妇126例作为对照组,比较三组的Cys-C、β2-MG、mALB水平和不良妊娠结局的发生情况,分析此三项指标与HDCP不良结局的相关性。结果 HP组、PE组和对照组的血清Cys-C、β2-MG及mALB水平差异显著,对照组的血清Cys-C、β2-MG及mALB水平明显低于PE组和HP组(P<0.05);对照组孕产妇的不良妊娠结局发生率显著低于PE组和HP组(P<0.05);血清Cys-C、β2-MG及mALB水平与HDCP不良结局发生的风险密切相关(P<0.05)。结论联合检测HDCP患者血清Cys-C、β2-MG及mALB,可用于指导临床采取有效的应对措施,促进母婴健康,对患者的预后有重要的临床意义。
Objective To explore the correlation between levels of serum cystatin C(Cys-C),β2-microglobulin(β2-MG) and urinary microalbumin(mALB) and adverse outcomes of hypertensive disorder complicating pregnancy(HDCP).Methods A total of 126 patients with HDCP who were admitted to People’s Hospital of Caoxian County and Heze Municipal Hospital were enrolled in the study. According to the disease progression degree, they were divided into pre-eclampsia(PE) group(48 cases) and gestational hypertension(HP) group(78 cases). 126 healthy pregnant women who underwent production inspection in the two hospitals during the same period were selected as the control group. The levels of Cys-C,β2-MG and mALB and the adverse pregnancy outcomes were compared among the three groups. The correlation between three indexes and adverse outcomes of HDCP was analyzed. Results There were significant differences in levels of serum CysC,β2-MG and mALB among HP group, PE group and control group. The levels of serum Cys-C,β2-MG and mALB in control group were significantly lower than those in PE group and HP group(P<0.05). The incidence of adverse pregnancy outcomes in control group was significantly lower than that in the other two groups(P<0.05). The levels of serum Cys-C,β2-MG and mALB were closely related to occurrence risk of HDCP adverse outcomes(P<0.05). Conclusion The combined detection of serum Cys-C,β2-MG and mALB has good predictive effect on early renal function injury of HDCP patients, which can be applied to guide clinical effective measures and promote maternal and child health. It is important for prognosis of HDCP patients.
作者
倪振旺
沙晗
NI Zhenwang;SHA Han(People's Hospital of Caoxian County;Heze Municipal Hospital,Heze 274000,Shandong)
出处
《菏泽医学专科学校学报》
2020年第1期5-7,共3页
Journal of Heze Medical College
关键词
妊娠期高血压
血清胱抑素C
Β2-微球蛋白
尿微量白蛋白
Hypertensive disorder complicating pregnancy
Serum cystatin C
β2-microglobulin
Urinary microalbumin
