摘要
目的评价阿尔茨海默病(Alzheimer's disease,AD)患者脑结构磁共振酰胺质子转移(amide proton transfer,APT)成像、磁敏感加权成像(susceptibility weighted imaging,SWI)相位值与神经心理量表评分的相关性.材料与方法募集20例AD患者和20名年龄及性别相匹配的正常对照者进行头颅常规序列、SWI和APT成像检查.在横断位APT像及SWI相位图上选取双侧海马、杏仁体、黑质,测量感兴趣区的酰胺质子(3.5 ppm处)不对称磁化转移率(magnetic resonance ratio asymmetry,MTRasym)及相位值.所有受试者均进行简易精神状态量表(mini-mental state examination,MMSE)评估,比较正常对照组和AD组各脑区MTRasym(3.5 ppm)值及相位值的差异.利用Pearson相关性分析所有受试者各脑结构MTRasym(3.5 ppm)值、相位值与MMSE评分的相关性.结果AD组双侧海马的MTRasym(3.5 ppm)值显著高于正常对照组[右侧:(1.39±0.17)%和(0.88±0.29)%,t=4.444,P=0.000;左侧:(1.42±0.31)%和(0.91±0.36)%,t=3.867,P=0.000].双侧海马、黑质的相位值AD组比正常对照组相位值减低(P<0.05).双侧海马的MTRasym(3.5 ppm)值均与MMSE评分呈负相关(右侧:r=-0.618,P=0.004;左侧:r=-0.513,P=0.021),双侧海马(右侧:r=0.446,P=0.049;左侧:r=0.518,P=0.019)及黑质(右侧:r=0.593,P=0.006;左侧:r=0.898,P=0.000)相位值与MMSE评分呈正相关.结论APT成像及SWI能够检验AD患者在海马及黑质的蛋白含量及铁含量变化,对AD诊断有一定帮助.
Objective:To evaluate the correlation between the phase values of magnetic resonance amido proton transfer(APT)imaging,magnetic sensitivity weighted imaging(SWI)and the scores of neuropsychological scale in patients with Alzheimer's disease(AD).Materials and Methods:Twenty AD patients and 20 age and gender matched normal controls were selected for routine skull sequence,SWI and APT imaging.The asymmetric magnetization transfer ratio(MTRasym)and phase value of amide protons(at 3.5 ppm)in the region of interest were measured by selecting bilateral hippocampus,amygdala and substantia nigra on the APT image and SWI phase map of the transection position.All subjects were assessed with mini mental state examination(MMSE).The difference of MTRasym(3.5 ppm)and phase value between normal control group and AD group was compared.Pearson correlation was used to analyze the correlation between the value of MTRasym(3.5 ppm),phase value and MMSE score.Results:the MTRasym(3.5 ppm)value of bilateral hippocampus in AD group was significantly higher than that in normal control group[right side:(1.39±0.17)%and(0.88±0.29)%,t=4.444,P=0.000;left side:(1.42±0.31)%and(0.91±0.36)%,t=3.867,P=0.000].The phase value of bilateral hippocampus and substantia nigra in AD group was lower than that in normal control group(P<0.05).The MTRasym(3.5ppm)value of bilateral hippocampus was negatively correlated with MMSE score(r=-0.618 on the right,P=0.004;r=-0.513 on the left,P=0.021),and the phase value of bilateral hippocampus(r=0.446 on the right,P=0.049;r=0.518 on the left,P=0.019) and substantia nigra(r=0.593 on the right,P=0.006;r=0.898 on the left,P=0.000)was positively correlated with MMSE score.Conclusions:APT and SWI imaging can detect the protein content and iron content in hippocampus and substantia nigra of AD patients sensitively,which is helpful for AD diagnosis.
作者
张聪
郑阳
王晓明
ZHANG Cong;ZHENG Yang;WANG Xiaoming(Department of Radiology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China)
出处
《磁共振成像》
CAS
2020年第6期406-410,共5页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金(编号:81471720)
辽宁省教育厅重点实验室基础研究项目(编号:LZ2014039)
盛京自由研究者基金(编号:201402)。
关键词
阿尔茨海默病
酰胺质子转移
磁敏感加权成像
海马
黑质
杏仁体
Alzheimer's disease
amide proton transfer
susceptibility-weighted imaging
hippocampus
substantia nigra
amygdaloid body
