摘要
目的探讨酰胺质子转移成像在颅脑基底节层面测量酰胺质子不对称磁化转移率(MTRasym)的可重复性。方法采用Philips公司3.0 T Achieva磁共振成像系统,头部8通道线圈,对11例健康志愿者在不同时间(7~30天内)进行两次酰胺质子转移成像。扫描完成后APT的图像分析采用交互式数据语言(interactive data language,IDL)的内部开发软件进行处理。由1名有经验的放射科医生仔细划定颅脑基底节层面的目标区域,采用组内相关系数(ICC)和BlandAltman法评价测量者自身的一致性,评价测量者自身的一致性,利用配对t检验分析两次测量结果的差异性,采用单因素方差分析分别对2次扫描基底节层面4个感兴趣区(ROI)的MTRasym值进行比较。检验前先对各组数据进行正态分布检验和方差齐性分析。结果 2次扫描颅脑不同层面的两次测量得到MTRasym值无统计学差异(P>0.05),组内相关系数和Bland-Altman评估分析两次测量可重复性良好。结论初步研究结果表明,磁共振酰胺质子转移成像测量酰胺质子不对称磁化转移率有较好的可重复性,可进一步用于颅脑基底节层面各病变的研究。
Objective To evaluate measurement reproducibility of MTRasym value in amide proton transfer （APT） imaging of health subjects. Methods 11 health subjects underwent APT imaging（between 7 clays and 30 days） and the image analysis was performed using the Interactive Data Language （IDL, ITY Visual Information Solutions, Boulder, CO, USA）. Regions of each lo- cation were carefully delineated by an experienced radiologist at the target areas of craniocerebral basal ganglia level. Repeatability between readers for each target areas was assessed by intraclass correlation coefficient （ICC） and Bland-Altman analysis. The re- sults between the two measurements were analyzed by paired-sample t test. One way ANOVA was used to compare the difference of MTRasym value among the four ROI at basal ganglia level. Results No statistical significance was found among different target areas. Great agreement was shown in measuring MTRasym value in amide proton transfer （APT） imaging of health subjects. Con- elusion MTRasym measurement has good inter- and intra-observer agreement in all locations.
出处
《医学影像学杂志》
2017年第5期789-792,共4页
Journal of Medical Imaging
关键词
磁共振成像
酰胺质子转移成像
颅脑
可重复性
Magnetic resonance imaging
Amide proton transfer imaging
Craniocerebrum
Repeatability
