摘要
神经影像学对阿尔茨海默病的诊断和鉴别具有重要价值,结构影像学尤其是结构磁共振能显示阿尔茨海默病的特征性脑萎缩改变,并能有效识别颅内其他病变,为阿尔茨海默病的鉴别诊断提供重要依据。正电子发射断层摄影术可实现对颅内β-淀粉样蛋白沉积的显像,对于阿尔茨海默病的病理生理诊断具有特殊价值。文中就结构和功能磁共振、分子影像学检查在阿尔茨海默病的诊断和鉴别方面的应用价值做一阐述。
Neuroimaging is of great value in the diagnosis and differentiation of Alzheimer′s disease.Structural imaging,especially structural magnetic resonance,can show the characteristic changes of brain atrophy in patients with Alzheimer′s disease,and effectively identify lesions in the brain.Functional imaging,mainly the molecular imaging of positron emission tomography can achieve intracranial retention of tracer that binds to theβ-amyloid,which is of great value for the pathophysiological diagnosis of Alzheimer′s disease.This article introduces the application value of structural and functional magnetic resonance imaging,positron emission tomography,single-photon emission computed tomography and other imaging examinations in the diagnosis and differentiation of Alzheimer′s disease.
作者
彭国平
刘晓燕
罗本燕
Peng Guoping;Liu Xiaoyan;Luo Benyan(Department of Neurology,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2020年第5期321-327,共7页
Chinese Journal of Neurology
基金
国家重点研发计划-重大慢性非传染性疾病防控研究项目(2016YFC1306402,2016YFC1306404)
国家重点研发计划-数字诊疗装备研发专项(2019YFC0118203)。
关键词
阿尔茨海默病
诊断
诊断
鉴别
神经影像学
Alzheimer disease
Diagnosis
Diagnosis,differential
Neuroimaging
