摘要
早期成长逆境是多种疾病的危险因素,但相关机制尚未明确。有研究线索提示早期成长逆境与生物学老化相关,而目前较为公认的生物学老化指标是端粒长度,故探究早期逆境与端粒长度的关联对揭示逆境的相关作用机制具有重要意义。本文通过对既往文献进行综述,探讨不同逆境类型、暴露时间及研究设计对早期逆境与端粒长度关联的可能影响,为早期成长逆境的干预提供一定依据。
Early life adversity is a risk factor for many diseases,but the related mechanism is not clear.Some research clues suggest that early life adversity is related to biological aging,and at present,the more recognized biological aging index is telomere length.Therefore,exploring the relationship between early life adversity and telomere length is of great significance to reveal the related mechanism of adversity.Through a review of previous literature,this paper discusses the possible effects of different adversity types,exposure time and research design on the relationship between early life adversity and telomere length,so as to provide a basis for the intervention of early life adversity.
作者
陈星星
孙莹
Chen Xingxing;Sun Ying(Department of Maternal,Child and Adolescent Health,School of Public Health,Anhui Medical University/Ministery of Education Key Laboratory of Population Health Across Life Cycle,Hefei 230032,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2020年第5期581-585,共5页
Chinese Journal of Preventive Medicine
基金
国家自然科学基金(81872638)
安徽省自然科学基金(1908085J26)。
关键词
生长
端粒
早期成长逆境
Growth
Telomere
Early life adversity
