摘要
目的探讨中性粒细胞/淋巴细胞(neutrophil to lymphocyte,NLR)与急性脑梗死复发的关系。方法收集2018年6月~2019年6月在徐州医科大学附属医院神经内科住院治疗的急性脑梗死患者186例,检测中性粒细胞计数、淋巴细胞计数、血糖、血脂等指标,并计算NLR;另收集同期健康体检者92例作为对照组。将患者进一步分为首发组和复发组。分别比较脑梗死组和对照组、首发组和复发组的中性粒细胞计数、淋巴细胞计数和NLR等,并做影响脑梗死复发的多因素分析和ROC曲线分析。结果脑梗死组NLR值高于对照组,且复发组高于首发组;多因素回归分析显示,NLR、同型半胱氨酸(Hcy)、年龄、高血压和心房颤动是脑梗死复发的独立危险因素;ROC曲线分析显示,NLR、Hcy、NLR+Hcy诊断脑梗死复发的曲线下面积分别为0.762、0.708、0.821,NLR诊断脑梗死复发的阈值为3.01,对应的敏感度和特异性分别为72.5%和71.9%;Hcy诊断脑梗死复发的阈值为22.8,对应的敏感度和特异性分别为54.9%和88.9%。结论NLR较高对预测脑梗死复发有一定价值。
Objective To discuss the relationship between neutrophils/lymphocytes and relapse of cerebral infarction.Methods Totally 186 patients with acute cerebral infarction hospitalized in Neurology Department,Xuzhou Affiliated Hospital from June 2018 to June 2019 were collected.Neutrophil count,lymphocyte count,blood glucose,and blood fat were detected.NLR was calculated.In the same period,92 health people were collected as the control group.Patients were further divided into the initial group and relapse group.Neutrophil count,lymphocyte count and NLR in the cerebral infarction group and control group,initial group and relapse group were compared respectively.Multi-factor analysis and ROC curve analysis of affecting relapse of cerebral infarction were conducted.Results NLR in the cerebral infarction was higher than the control group.Also,the relapse group was higher than the initial group.Multi-factor regression analysis showed that NLR,Hcy,age,hypertension and auricular fibrillation were independent risk factors for relapse of cerebral infarction.ROC curve analysis revealed that area under the curve(AUC)for relapse of cerebral infarction with NLR,Hcy,age,hypertension and auricular fibrillation respectively included 0.762,0.708 and 0.821.The threshold for relapse of cerebral infarction diagnosed by NLR was 3.01.The corresponding sensitivity and specificity respectively reached 72.5%and 71.9%.The threshold for relapse of cerebral infarction diagnosed by Hcy was 22.8.The corresponding sensitivity and specificity respectively reached 54.9%and 88.9%.Conclusion The higher NLR has some values for predicting relapse of cerebral infarction.
作者
刘洁
陈璐
黄小雨
肖成华
王炎强
Liu Jie;Chen Lu;Huang Xiaoyu(Graduate School,Xuzhou Medical University,Jiangsu 221002,China)
出处
《医学研究杂志》
2020年第6期61-65,共5页
Journal of Medical Research
基金
国家自然科学基金资助项目(81870943)。
