摘要
目的研究中性粒细胞/淋巴细胞比值（neutrophil lymphocyte ratio,NLR）与颅外颈动脉狭窄的相关性。方法回顾性分析2005-2015年在北京大学人民医院进行全脑数字减影血管造影检查显示为正常和单纯颅外颈动脉狭窄的患者共129例,按颈动脉狭窄的程度分为5组,无狭窄组27例,轻度狭窄组30例（1%-49%）,中度狭窄组19例（50%-69%）,重度狭窄组34例（70%-99%）和闭塞组19例（100%）,计算NLR,并进行比较。使用有序多分类logistic回归分析颅外颈动脉狭窄的危险因素。结果无狭窄组、轻度狭窄组、中度狭窄组、重度狭窄组和闭塞组的高血压比例分别为37.04%、66.67%、73.68%、70.59%、63.16%,糖尿病比例分别为14.81%、33.33%、57.89%、41.18%、42.11%,脑梗死比例分别为7.41%、30.00%、36.84%、55.88%、57.89%,NLR分别为1.46±0.42、1.73±0.45、2.37±0.82、2.41±0.82和2.75±1.31,各组比较差异有统计学意义（P=0.048,P=0.041,P=0.001,P=0.000）。有序多分类logistic回归显示NLR（OR=3.146,95%CI：1.919-5.340,P=0.000）和年龄（OR=1.682,95%CI：1.197-2.340,P=0.002）为颅外颈动脉狭窄的独立危险因素。结论 NLR与颅外颈动脉狭窄的风险具有相关性。
Objective To study the correlation between neutrophil/lymphocyte ratio（NLR）and extarcranial carotid stenosis.Methods One hundred and twenty-nine patients with extarcranial carotid stenosis detected by DSA in our hospital from 2005 to 2015were divided into non-stenosis group（n=27）,mild stenosis group（1%-49%,n=30）,moderate stenosis group（50%-69%,n=19）,severe stenosis group（70%-99%,n=34）and occlusion group（100%,n=19）.Their NLR was calculated and compared.Risk factors for extarcranial carotid stenosis were analyzed by ordinal logistic regression analysis.Results The ratio of hypertension,diabetes and ischemic stroke and NLR of patients in normal group,mild stenosis group,moderate stenosis group,severe stenosis group and occlusion group was 37.04%,66.67%,73.68%,70.59%,63.16%（P=0.048）,14.81%,33.33%,57.89%,41.18%,42.11%（P=0.041）,7.41%,30.00%,36.84%,55.88%,57.89%（P=0.001）,and 1.46±0.42,1.73±0.45,2.37±0.82,2.41±0.82 and 2.75±1.31（P=0.000）respectively.Ordinal logistic regression analysis showed NLR（OR=3.146,95%CI：1.919-5.340,P=0.000）,and age（OR=1.682,95%CI：1.197-2.340,P=0.002）were the independent risk factor carotid stenosis.Conclusion NLR is correlated with the risk of extarcranial carotid stenosis.
出处
《中华老年心脑血管病杂志》
CAS
2016年第1期55-58,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
